Compare the effect of diode laser and photoactivated disinfection on postoperative pain and periapical healing following root canal treatment – A Randomized Controlled Clinical Trial..

Phase 2/3

Not yet recruiting

Conditions: Acute apical periodontitis of pulpal origin,

Registration Number: CTRI/2025/05/086766

Lead Sponsor: Samiya Kulsoom

Brief Summary: The effectiveness of endodontic treatment largely depends on the removal of bacteria and irritants from the root canal prior to obturation. Chemical debridement aids in the elimination of residual tissue and bacterial biofilm, particularly from the non-instrumented region of the root canal system. In recent year, intracanal laser has emerged as an adjunctive treatment for endodontic procedure. The aim of this randomized controlled trial is to evaluate the difference in postoperative pain and periapical healing following root canal treatment with diode laser and photoactivated disinfection used for root canal irrigation. The null hypothesis is that there is no significant difference in postoperative pain and periapical healing between the two treatment methods.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 75

Inclusion Criteria

Patients must agree to participate, single rooted teeth with pulp necrosis and symptomatic apical periodontitis, Radiographic evidence of periapical radiolucency with PAI score more than or equal to three.

Exclusion Criteria

Teeth with immature roots.
Calcified canals.
Poor restorative, or periodontal prognosis.
Antibiotic use within the last month.
Anti-inflammatory analgesic use within the last 5 days.
Patients with any uncontrolled systemic disease.
Pregnant or Lactating females.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post operative pain	4, 24, 48, and 72-hour postoperative intervals.

Secondary Outcome Measures

Name	Time	Method
Periapical healing	3, 6 and 12 months after root canal treatment.

Trial Locations

Locations (1): Dr. Ziauddin Ahmad Dental College, AMU
🇮🇳
Aligarh, UTTAR PRADESH, India
Dr. Ziauddin Ahmad Dental College, AMU
🇮🇳Aligarh, UTTAR PRADESH, India
Dr Samiya Kulsoom
Principal investigator
7701903485
samiyakulsoom@gmail.com