Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Severe Community-acquired Pneumonia
- Sponsor
- Capital Medical University
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Hospital mortality
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the best treatment strategy has not been determined. Based on this, this project intends to take patients with severe community-acquired pneumonia caused by different pathogens as the research object, explore the molecular mechanism of severe community-acquired pneumonia from multiple angles, integrate relevant research data to evaluate the rationality of initial empirical medication, and lay the foundation for precise treatment of severe pneumonia. The research results will help to develop a new rapid and accurate target for clinical diagnosis and efficacy evaluation of severe pneumonia, and build a precise treatment system for severe pneumonia.
Investigators
Zhaohui Tong
Clinical Professor
Capital Medical University
Eligibility Criteria
Inclusion Criteria
- •Age\> 18 years old
- •Clinical diagnosis of community-acquired pneumonia
Exclusion Criteria
- •Pregnancy, perinatal and lactating women
- •Combined immunosuppressive diseases: such as HIV, solid organ transplantation, solid organ/hematologic malignant tumor chemotherapy, rheumatic diseases or glomerular diseases need to take hormone/immunosuppressant therapy
- •Combined blood system diseases: such as leukemia reactions, aplastic anemia, neutropenia or deficiency of granulocytes, previous bone marrow/stem cell transplantation
Outcomes
Primary Outcomes
Hospital mortality
Time Frame: during hospitalization (up to day 14)
Secondary Outcomes
- Length of ICU stay(during hospitalization (up to day 14))
- Expense during hospitalization(during hospitalization (up to day 14))
- Cause of death(during hospitalization (up to day 14))
- Length of stay(during hospitalization (up to day 14))