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临床试验/NCT06288074
NCT06288074招募中不适用

Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration

Capital Medical University1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2024年3月10日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
300
试验地点
1
主要终点
Hospital mortality

研究概览

简要总结

Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the best treatment strategy has not been determined. Based on this, this project intends to take patients with severe community-acquired pneumonia caused by different pathogens as the research object, explore the molecular mechanism of severe community-acquired pneumonia from multiple angles, integrate relevant research data to evaluate the rationality of initial empirical medication, and lay the foundation for precise treatment of severe pneumonia. The research results will help to develop a new rapid and accurate target for clinical diagnosis and efficacy evaluation of severe pneumonia, and build a precise treatment system for severe pneumonia.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age> 18 years old
  • Clinical diagnosis of community-acquired pneumonia

排除标准

  • Pregnancy, perinatal and lactating women
  • Combined immunosuppressive diseases: such as HIV, solid organ transplantation, solid organ/hematologic malignant tumor chemotherapy, rheumatic diseases or glomerular diseases need to take hormone/immunosuppressant therapy
  • Combined blood system diseases: such as leukemia reactions, aplastic anemia, neutropenia or deficiency of granulocytes, previous bone marrow/stem cell transplantation

结局指标

主要结局

Hospital mortality

时间窗: during hospitalization (up to day 14)

次要结局

  • Length of ICU stay(during hospitalization (up to day 14))
  • Expense during hospitalization(during hospitalization (up to day 14))
  • Cause of death(during hospitalization (up to day 14))
  • Length of stay(during hospitalization (up to day 14))

研究者

发起方
Capital Medical University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Zhaohui Tong

Clinical Professor

Capital Medical University

研究点 (1)

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