Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Hospital mortality
研究概览
简要总结
Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the best treatment strategy has not been determined. Based on this, this project intends to take patients with severe community-acquired pneumonia caused by different pathogens as the research object, explore the molecular mechanism of severe community-acquired pneumonia from multiple angles, integrate relevant research data to evaluate the rationality of initial empirical medication, and lay the foundation for precise treatment of severe pneumonia. The research results will help to develop a new rapid and accurate target for clinical diagnosis and efficacy evaluation of severe pneumonia, and build a precise treatment system for severe pneumonia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age> 18 years old
- •Clinical diagnosis of community-acquired pneumonia
排除标准
- •Pregnancy, perinatal and lactating women
- •Combined immunosuppressive diseases: such as HIV, solid organ transplantation, solid organ/hematologic malignant tumor chemotherapy, rheumatic diseases or glomerular diseases need to take hormone/immunosuppressant therapy
- •Combined blood system diseases: such as leukemia reactions, aplastic anemia, neutropenia or deficiency of granulocytes, previous bone marrow/stem cell transplantation
结局指标
主要结局
Hospital mortality
时间窗: during hospitalization (up to day 14)
次要结局
- Length of ICU stay(during hospitalization (up to day 14))
- Expense during hospitalization(during hospitalization (up to day 14))
- Cause of death(during hospitalization (up to day 14))
- Length of stay(during hospitalization (up to day 14))
研究者
Zhaohui Tong
Clinical Professor
Capital Medical University
