Analysis of Inflammation in the Vitiligo and Other Inflammatory Skin Diseases: Psoriasis, Atopic Dermatitis and Alopecia Areata

• Conditions: Psoriasis; Alopecia Areata; Vitiligo; Atopic Dermatitis
• Interventions: Biological: Blood samples; Biological: Skin biopsies

• Registration Number: NCT03976622
• Lead Sponsor: University Hospital, Bordeaux

Brief Summary

It is a study of translational research with mechanistically objectives and including biological samples of patients with chronic inflammatory disorders

Detailed Description

This study was a single-center prospective study to collect blood and skin tissue at the time of consultation with a patient with non-segmental vitiligo, psoriasis, atopic dermatitis or alopecia areata, in order to better understand and compare blood and skin immune response in chronic inflammatory skin disorders: psoriasis, alopecia areata, atopic dermatitis and vitiligo.

Study Timeline

• Status Verified: 2019-05
• Study Start: 2019-06-03
• Study First Submitted: 2019-06-03
• Study First Submitted QC: 2019-06-03
• Last Update Submitted: 2019-06-03
• Study First Posted: 2019-06-06
• Last Update Posted: 2019-06-06
• Primary Completion: 2023-06-03
• Study Completion: 2023-06-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• Patients aged 18 to 75 years;
• Patients with non-segmental vitiligo;
• Patients with plaque psoriasis;
• Patients with atopic dermatitis;
• Patients with alopecia areata sclerosis;
• written consent, free, informed and signed by the patient and the investigator (before any examination required by the study);
• Subject affiliated or beneficiary of a social security system.

Exclusion Criteria

• Patients with segmental vitiligo
• Patients under local treatment (topical corticosteroid-Calcineurin inhibitor) for less than two weeks.
• Patients on therapy, systemic treatments: acitretin, methotrexate, cyclosporine, Apremilast, infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, dupilumab) for less than 4 weeks.
• Pregnant or breastfeeding women
• Patient (e) under guardianship
• Patient (e) Non-affiliated (e) a social protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
psoriasis	Skin biopsies	Patients aged 18 to 75 years with plaque psoriasis;
vitiligo	Blood samples	Patients aged 18 to 75 years with non-segmental vitiligo;
atopic dermatitis	Blood samples	Patients aged 18 to 75 years with atopic dermatitis;
atopic dermatitis	Skin biopsies	Patients aged 18 to 75 years with atopic dermatitis;
alopecia areata	Blood samples	Patients aged 18 to 75 years with alopecia areata sclerosis;
psoriasis	Blood samples	Patients aged 18 to 75 years with plaque psoriasis;
alopecia areata	Skin biopsies	Patients aged 18 to 75 years with alopecia areata sclerosis;
vitiligo	Skin biopsies	Patients aged 18 to 75 years with non-segmental vitiligo;

Primary Outcome Measures

Name	Time	Method
Description of the phenotype and function of blood and skin T-cell in chronic inflammatory skin disorders: psoriasis, vitiligo, atopic dermatitis, alopecia areata	Day 1	Description of the phenotypic analysis of cutaneous T-cell and blood of vitiligo patients evaluated by flow cytometry

Trial Locations

Locations (1)

Service de Dermatologie - Hôpital Saint-André; 🇫🇷 Bordeaux, France