Evaluation of safety and efficacy of Curcumin- Piperine- Lycopene combination versus Calcium Hydroxide as Intracanal Medicaments on pain relief in symptomatic Irreversible Pulpitis.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The curcumin-based group is expected to show a statistically significant reduction in inter-appointment pain and tenderness better or comparable outcome to traditional agents like calcium hydroxide .
研究概览
简要总结
This study is randomized double blind parallel group trial comparing the safety and efficacy of Curcumin 500 mg, Piperine 5 mg, Lycopene 10 mg combination and Calcium Hydroxide as intracanal medicament for 7 days in 60 patients with symptomatic irreversible pulpitis that will be conducted in AIIMS Guwahati. The primary outcome likely that Curcumin based combination is expected to show a statistically significant reduction in inter-appointment pain and tenderness better or comparable to calcium hydroxide measured at 1st, 3rd, 5th and 7th day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient visiting Out Patient Department at AIIMS Guwahati ii.
- •Single rooted maxillary and mandibular teeth with irreversible pulpitis iv.Informed Consent.
排除标准
- •Failure to give consent ii.
- •Medically comprised iii.
- •Pregnant patient iv.
- •More than 1 root canal in tooth v.
- •Teeth with Periapical radiolucency vi Had taken medication within 12 hrs of study.
结局指标
主要结局
The curcumin-based group is expected to show a statistically significant reduction in inter-appointment pain and tenderness better or comparable outcome to traditional agents like calcium hydroxide .
时间窗: 1st day 3rd day 5th day 7th day
The study anticipates fewer analgesic requirements
时间窗: 1st day 3rd day 5th day 7th day
With better healing and recovery, prognosis of root canal treated teeth will be improved.
时间窗: 1st day 3rd day 5th day 7th day
次要结局
未报告次要终点
研究者
Dr Krishna Prasad Biswas
AIIMS Guwahati