The Effect of Environmental Enrichment and Stress on Psoriasis

Not Applicable

• Conditions: Psoriasis; Psychological Stress; Skin - Dermatological conditions; Mental Health - Other mental health disorders

• Registration Number: ACTRN12619000681156
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-07
• Study Completion: 2020-07-20
• Last Update Posted: 16 October 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Have chronic plaque psoriasis
Over 16 years of age
Can read and write in English fluently
Can provide written informed consent

Exclusion Criteria

Have another significant dermatological condition
People on any current systemic (oral) therapy for psoriasis including cyclosporin, methotrexate, acitretin, biologic agents or phototherapy. If they have recently stopped systemic treatments for psoriasis, they must be off all systemic treatments for at least 3 months
People on any other immunosuppressive medication, such as systemic corticosteroids
People who have recently changed depression or anxiety medications

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in trans-epidermal water loss (TEWL) as measured using the Tewameter TM 300[Baseline, immediately after the stress task and immediately after the 30 minute intervention];Change in chemical and biological composition of the psoriatic lesion as measured using Raman Spectroscopy[Baseline, immediately after the stress task and immediately after the 30 minute intervention]

Secondary Outcome Measures

Name	Time	Method
Mood as measured by the PANAS scale[Baseline, immediately after the stress task and immediately after the 30 minute intervention];Changes in current stress levels as measured using 100mm visual analogue scales[Baseline, immediately after the stress task and immediately after the 30 minute intervention];Changes in current anxiety levels as measured using 100mm visual analogue scales[Baseline, immediately after the stress task and immediately after the 30 minute intervention<br>];Changes in current pain levels as measured using 100mm visual analogue scales[Baseline, immediately after the stress task and immediately after the 30 minute intervention];Changes in current relaxation levels as measured using 100mm visual analogue scales[Baseline, immediately after the stress task and immediately after the 30 minute intervention]