Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection

• Conditions: Bone Tumours; Bone Infection; Prosthetic Infection; Prosthetic Joint Infection
• Interventions: Diagnostic Test: Genomic sequencing; Diagnostic Test: Histological examination

• Registration Number: NCT04746001
• Lead Sponsor: Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

Brief Summary

Translational research aimed at improving diagnostic accuracy of musculoskeletal infection and musculoskeletal tumours using machine learning applied to clinical data, histopathological sections and genomic sequencing.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-02-08
• Study First Submitted QC: 2021-02-08
• Study First Posted: 2021-02-09
• Study Start: 2021-06-28
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-10
• Last Update Posted: 2021-11-11
• Primary Completion: 2024-01-01
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Suspected infection of bone tumour and biopsy taken for analysis

Exclusion Criteria

Patient doesn't consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Infection	Genomic sequencing	-
Infection	Histological examination	-
Tumours	Genomic sequencing	-
Tumours	Histological examination	-

Primary Outcome Measures

Name	Time	Method
Sequencing data and identification	3 years	Identification of infection and tumours using sequencing data
Histological slides and identification	3 years	Deep learning using histological images

Trial Locations

Locations (1)

Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust; 🇬🇧 Oswestry, Shropsire, United Kingdom