A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12,215
- 试验地点
- 1
- 主要终点
- high quality embryo rate for ICSI
研究概览
简要总结
The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total progressive sperm number of 2 x 10^6 after pretreatment as the boundary value, and will divide total progressive sperm number of 2 x 10^6 after pretreatment into 2 x 10^6 or higher and < 2 x 10^6 groups, and will further divide < 2 x 10^6 group into: = 0, (0,10^6], (10^6, 2 x 10^6) three groups. Propensity score matching will be used to balance the baseline data between four groups. The matching variables are age, female BMI, AFC, AMH and ICSI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •infertility female and sterility male for reproductive treatment
排除标准
- •chromosomal abnormalities
- •none retrieval oocyte
- •none oocyte for ICSI
- •Recurrent abortion
- •female age≥37 years
- •Assisted hatching
- •abnormal oocyte zona pellucida
- •In Vitro Maturation
- •AZF microdeletion
结局指标
主要结局
high quality embryo rate for ICSI
时间窗: two years
rate of embryo grade above 6CI on the third day after fertilization
次要结局
- fertilization rate of ICSI(two years)
- normal fertilization rate of ICSI(two years)