Multifocal electroretinogram abnormalities in inflammatory cystoid macular edema.

Completed

Conditions: cystoid macular edema
uveitis
10015919

Registration Number: NL-OMON47097

Lead Sponsor: MC Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Age *18 years
- Inflammatory CME requiring (different) treatment
- Mentally competent

Exclusion Criteria

- Age <18 years
- Patients diagnosed with diabetes, a retinal occlusion or other causes of CME.
- Patients with a history of treatment with medication that alter macular function i.e. hydroxychloroquine, tamoxifen.
- Patients with severe puckering
- Patients diagnosed with conditions other than uveitis, that can influence macular function i.e. age related macular degeneration, Stargardt etc.
- Patients with a severe vitreous haze or severe cataracts

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate to which extent macular function is affected in patients with<br /><br>inflammatory CME as measured by mfERG. Multifocal ERGs will be analyzed on<br /><br>amplitude, implicit time, and waveform. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To which extent mfERG abnormalities are reversible after treatment.<br /><br>2. To which extent clinical parameters, including demographics, treatment and<br /><br>ophthalmologic examination results (e.g. OCT value, visual acuity, severity of<br /><br>inflammation scored according to SUN) influence and/or correlate to mfERG<br /><br>abnormalities.<br /><br>3. To which extend the 30HZ flicker response can be correlated to the mfERG<br /><br>and clinical parameters.</p><br>