CTRI/2025/07/091175尚未招募4 期
A comparative study evaluating the effects of propofol and Nitroglycerine infusion on patients hemodynamic while weaning off from cardiopulmonary bypass posted for cardiac surgery
Dr Kanchan Gupta1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年7月31日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The effect of propofol infusion in achieving vasodilation and controlled hypotension perioperatively as compared to Nitroglycerine infusion.
研究概览
简要总结
This study is the randomized, double blinded study comparing the effects of propofol and Nitroglycerine infusion on patients hemodynamic while weaning off from cardiopulmonary bypass posted for cardiac surgery. The Primary objective is to measure the changes in hemodynamic such as vasodilation and controlled hypotension perioperatively while using these above mentioned drugs. The secondary objective is to compare the ionotropic requirement while using these drugs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients posted for Cardiac Surgeries.
排除标准
- •Patients not willing to give informed consent
- •Extremes of age
- •Patients posted for CABG
- •Patients with severe systolic LV dysfunction.
- •5.patients posted for combined cardiac and major vascular surgeries.
- •Cardio-pulmonary Bypass time more than 90 minutes.
- •HbA1c more than 6.5.
结局指标
主要结局
The effect of propofol infusion in achieving vasodilation and controlled hypotension perioperatively as compared to Nitroglycerine infusion.
时间窗: while weaning off from cardio-pulmonary bypass
次要结局
- 1. Comparison of total ionotropic requirement after separation of cardiopulmonary bypass among the two groups.(2. Comparison of hemodynamic fluctuations while shifting the patients from Operating room to ICU among the two groups.)
研究者
Kanchan Gupta
King Georges Medical University
研究点 (1)
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