Pharmacokinetic study of the HCV protease inhibitor bocePRevir and the proton pump inhibitor OMeprazOle (PROMO) - PROMO

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•1. Subject is at least 18 and not older than 55 years at screening.
•2. Subject des not smoke more than 10 cigarettes, 2 cigars, or 2 pipes per day for at least 3 months prior to the first dosing
•3. Subject has a Quetelet Index (Body Mass Index) of 18 to 30 kg/m2, extremes included.
•4. Subject is able and willing to sign the Informed Consent Form prior to screening evaluations.
•5. Subject is in good age-appropriate health condition as estab-lished by medical history, physical examination, electrocardi-ography, results of biochemistry, haematology and urinalysis testing within 4 weeks prior to Day 1. Results of biochemistry, haematology and urinalysis testing should be within the laboratory's reference ranges. If laboratory results are not within the reference ranges, the subject is included on condition that the Investigator judges that the deviations are not clinically relevant. This should be clearly recorded.
•6. Subject has a normal blood pressure and pulse rate, according to the Investigator's judgement.

•1. Documented history of sensitivity/idiosyncrasy to medicinal products or excipients.
•2. Positive HIV test.
•3. Positive hepatitis B or C test.
•4. Pregnant female (as confirmed by an HCG test performed less than 4 weeks before Day 1) or breast-feeding female. Female subjects of childbearing potential without adequate contraception, e.g. hysterectomy, bilateral tubal ligation, (non-hormonal) intrauterine device, total abstinence, double barrier methods, or two years post-menopausal. They must agree to take precautions in order to prevent a pregnancy throughout the entire conduct of the trial.
•5. Therapy with any drug (for two weeks preceding dosing), except for paracetamol.
•6. Relevant history or presence of pulmonary disorders (especially COPD), cardiovascular disorders, neurological disorders (especially seizures and migraine), psychiatric disorders, gastro-intestinal disorders, renal and hepatic disorders, hormonal dis-orders (especially diabetes mellitus), coagulation disorders.
•7. Relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion.
•8. History of or current abuse of drugs, alcohol or solvents.
•9. Inability to understand the nature and extent of the trial and the procedures required.
•10. Participation in a drug trial within 60 days prior to the first dose.
•11. Donation of blood within 60 days prior to the first dose.
•12. Febrile illness within 3 days before Day 1.

发起方

niversitair Medisch Centrum Sint Radboud