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临床试验/NCT01305603
NCT01305603已完成不适用

Dual TAP Block Characteristics - Evaluation of Local Anesthetic Distribution by MR Scanning

Bispebjerg Hospital1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2011年2月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
10
试验地点
1
主要终点
Distribution of local anesthetic evaluated by MR scanning

研究概览

简要总结

Using Magnetic resonance (MR) scanning and ultrasonography the investigators wish to investigate, in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

详细描述

There has been much debate as to what extent the classical TAP block will anesthetize more than the frontal dermatomes (TH10-Th12/L1). Some cadaver studies have been performed with injection of dye in the classical TAP. However, it is still not clear whether a single injection of local anesthetic in the classical TAP block position will reach the more cephalad and medial intercostal TAP plexus (Th6-Th9). In this study the investigators use MR scanning and ultrasonography to investigate in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • healthy male
  • 18 years old or more
  • had no previous abdominal surgery
  • no regular medication
  • no coagulation disorders
  • no claustrophobia

排除标准

  • if the volunteer is not able to accept an uncomplicated administration of a classical (single) or dual TAP block

研究组 & 干预措施

Dual TAP block

Active Comparator

Dual TAP block on one side on the abdomen. Classical (or single) TAP on the contra lateral side of the abdomen; supplemented with a sham injection to ensure double blindness.

干预措施: Bupivacaine (Drug)

Dual TAP block

Active Comparator

Dual TAP block on one side on the abdomen. Classical (or single) TAP on the contra lateral side of the abdomen; supplemented with a sham injection to ensure double blindness.

干预措施: Injection (Procedure)

Classical (or single) TAP block

Active Comparator

Dual TAP block on one side on the abdomen. Classical (or single) TAP on the contra lateral side of the abdomen; supplemented with a sham injection to ensure double blindness

干预措施: Bupivacaine (Drug)

Classical (or single) TAP block

Active Comparator

Dual TAP block on one side on the abdomen. Classical (or single) TAP on the contra lateral side of the abdomen; supplemented with a sham injection to ensure double blindness

干预措施: Injection (Procedure)

结局指标

主要结局

Distribution of local anesthetic evaluated by MR scanning

时间窗: 30 minutes after administering the TAP blocks

次要结局

  • Spread of anesthetized frontal dermatomes(30 minutes after administering the TAP blocks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jens Borglum Neimann

Jens Børglum Neimann, MD, PhD, MBA, Consultant Anesthetist, Bispebjerg Hospital, Copenhagen University Hospital, Department of Anesthesia and Intensive Care Medicine, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark

Bispebjerg Hospital

研究点 (1)

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