Comparing different methods of monitoring pain, heart rate and blood pressure with opioid and non opioid medicines in patients undergoing the brain surgeries.
Not Applicable
Completed
- Conditions
- Health Condition 1: D330- Benign neoplasm of brain, supratentorial
- Registration Number
- CTRI/2023/02/050005
- Lead Sponsor
- ATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 58
Inclusion Criteria
Patients aged between 18 and 65years of ASA I and II
-Patients undergoing elective supratentorial craniotomy
Exclusion Criteria
-Patients in whom dexmedetomidine is contraindicated (second and third degree heart block),
-Patients in whom ANI will be unreliable (patients with pacemakers, patients on drugs affecting
sinus node, patients having arrhythmias).
-Patients with liver and renal diseases.
-Patients on gabapentinoids, tricyclic antidepressants and other analgesics
-Patients posted for aneurysmal clipping
-Patients with decreased sensorium
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the magnitude of change and response time in ANI, SPI and hemodynamic parameters (HR and MAP) to various noxious stimuli between patients receiving OFA with dexmedetomidine and those receiving opioid analgesia with fentanyl for <br/ ><br>supratentorial craniotomies. <br/ ><br>(Response time is the time taken for the parameter to change maximally due to noxious <br/ ><br>stimuli from the pre-stimuli value, i.e. lowest for the ANI and highest for SPI, HR and <br/ ><br>BP) <br/ ><br>(Magnitude of change is the difference between highest/lowest value after stimulation as compared to baseline i.e. pre-stimuli value)Timepoint: Before starting analgesic drug infusion and after 5 min and 10 min of starting infusion. At Intubation, skull pin insertion, skin incision, first burr hole placement, and durotomy.
- Secondary Outcome Measures
Name Time Method -To compare the magnitude of change and response timein ANI, SPI, hemodynamics with in the group <br/ ><br>-To determine and correlation between ANI and SPI in patients receiving opioid and OFATimepoint: Before starting analgesic drug infusion and after 5 min and 10 min of starting infusion. At Intubation, skull pin insertion, skin incision, first burr hole placement, and durotomy.