Investigating the Anabolic Response to Resistance Exercise After Critical Illness: The ARTIST-2 Non-Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Muscle protein fractional synthetic rate
研究概览
简要总结
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
The aim of this study is to investigate the effects of resistance exercise on muscle protein synthesis in former ICU patients. The investigators hypothesize that study subjects recovering from critical illness have an impaired anabolic response to resistance exercise after ICU stay as compared to non-critically ill controls.
详细描述
Background
The debilitating impact of critical illness has been recognized for several decades. Disability related to intensive care is now described as a syndrome called ICU-acquired weakness (ICUAW). ICUAW affects up to 70% of ICU patients and is most common with higher illness severity. Patients that develop ICUAW require longer hospitalization and have a higher risk of death. Weakness may persists for several years in ICU survivors. It has significant long-term consequences, and is associated with increased health care costs, delayed return to work, and overall poor quality of life.
Muscle atrophy is a major contributor to ICUAW. Critical illness is associated with a rapid loss of skeletal muscle, induced by catabolic signals from proinflammatory cytokines and hormones. The ability to regain lost muscle mass during convalescence may also be impaired. In a small observational study, muscle atrophy resolved only in a minority of ICU survivors at six months after ICU discharge.
Studies in exercise physiology have demonstrated that resistance training and amino acid ingestion have synergistic effects on muscle protein synthesis in healthy subjects. It is therefore an appealing therapy to reconstitute muscle mass after critical illness. Despite several clinical trials, there is equipoise regarding the efficacy of exercise in improving physical function in-ICU after ICU discharge. These mixed signals are unsurprising given the heterogeneous causes of ICUAW.
Only a few studies in this field have examined muscle architecture or cellular signaling in response to training. However, the gold standard in determining the anabolic response to exercise is to directly measure the effects on protein synthesis and breakdown. There is still no published research using this methodology to assess the effects of exercise interventions in former ICU patients. To understand the role of physical exercise in regaining lost muscle mass, the investigators plan to investigate the anabolic effects to resistance training after critical illness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult (≥18 years) previously admitted to an ICU at Karolinska University Hospital for ≥3 days and discharged alive from hospital
- •Adult (≥18 years) without a history of ICU admission (control group)
排除标准
- •Not able to provide informed consent
- •>6 months since ICU discharge*
- •Warfarin or dual antiplatelet therapy
- •Clinically significant inherited or acquired disorder of hemostasis
- •Lower-limb amputee
- •Lower-limb atherosclerotic disease with critical ischemia.
- •Recent fracture in lower limbs or significant osteoarthritis limiting movement in knee or hip joint
- •Metastatic cancer or active hematological malignancy
- •Inherited disorder of amino acid metabolism.
- •Chronic muscle, neuromuscular or neurologic disease with prior documentation of clinically significant lower-limb involvement
- •Single organ failure not requiring invasive mechanical ventilation during ICU stay*
- •Intubated only for airway protection with no other organ failure(s) during ICU stay*
- •Planned postoperative care in ICU after elective cardiothoracic surgery*
- •Exclusion criteria marked with asterisk only apply to former ICU patients.
研究组 & 干预措施
Former ICU patients
Research subjects with a prior history of ICU treatment within six months.
干预措施: Resistance exercise (Procedure)
Former ICU patients
Research subjects with a prior history of ICU treatment within six months.
干预措施: Oral protein supplementation (Dietary Supplement)
Age- and sex-matched control group
Research subjects without a prior history of ICU treatment within the last 30 years, age- and sex-matched in a 1:2 ratio to the experimental arm.
干预措施: Resistance exercise (Procedure)
Age- and sex-matched control group
Research subjects without a prior history of ICU treatment within the last 30 years, age- and sex-matched in a 1:2 ratio to the experimental arm.
干预措施: Oral protein supplementation (Dietary Supplement)
结局指标
主要结局
Muscle protein fractional synthetic rate
时间窗: 150 minutes post-exercise.
The difference between the experimental and active comparator group in muscle protein fractional synthetic rate.
次要结局
- Gene expression(150 minutes post-exercise.)
- Signaling pathways(150 minutes post-exercise.)
研究者
Martin Sundstrom Rehal
Principal Investigator
Karolinska University Hospital