Does stimulation of gastrointestinal bitter taste receptors reduce energy intake and improve postprandial glycaemia in type 2 diabetes?

niversity of Adelaide0 个研究点目标入组 16 人开始时间: 2018年10月26日最近更新: 2018年11月12日

适应症

试验速览

暂无简介。

•Type 2 diabetes (World Health Organisation (WHO) criteria), managed by diet or metformin only
•Body mass index (BMI) from 20 to 40 kg/m2
•Age from 50 to 75 years
•Males and post-menopausal females
•Glycated haemoglobin (HbA1c) equal to 8.5%
•Haemoglobin above the lower limit of the normal range (ie. greater than 135g/L for men and 115g/L for women), and ferritin above the lower limit of normal (ie. more than 30ng/mL for men and greater than 20mg/mL for women)

•Use of any medication that may influence gastrointestinal motor function within 48 hours or 5 half-lives of the study, specifically: opiates, anticholinergics, levodopa, beta-blockers, clonidine, nitrates, phosphodiesterase type 5 inhibitors, sumatriptan, metoclopramide, domperidone, cisapride, tegaserod, or erythromycin
•Evidence of drug abuse, or consumption of more than 20 g alcohol or 10 cigarettes on a daily basis
•History of gastrointestinal disease, including significant upper or lower gastrointestinal symptoms, pancreatitis, or previous gastrointestinal surgery (other than uncomplicated appendicectomy or cholecystectomy)
•Other significant illness, including epilepsy, cardiovascular or respiratory disease
•Impaired renal or liver function (as assessed by calculated creatinine clearance less than 90 mL/min or abnormal liver function tests (more than 2 times upper limit of normal range))
•Donation of blood within the previous 3 months
•Participation in any other research studies within the previous 3 months
•Females who are pre-menopausal
•Inability to give informed consent
•Participants who do not eat beef
•Vegetarian diet

发起方

niversity of Adelaide