Roles of T Helper 1 Cytokines in Type 1 Diabetes
- Conditions
- Type 1 Diabetes
- Registration Number
- NCT02389335
- Lead Sponsor
- Istanbul Medeniyet University
- Brief Summary
The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.
- Detailed Description
T helper (h)1 cells are known to have important roles in the destruction or/and dedifferentiation of β-cells in type 1 diabetes (T1D). Significant increase in IFN-γ-producing Th1 cells in the pancreas and in the serum levels were determined in type 1 diabetic patients at diabetes oneset. This data indicated that this proinflammatory mediator serve as a biomarker of advanced autoimmunity. We aimed to investigate the relationship between Th1 cytokines (IFN-γ, IL-2 and TNF-α) and T1D and the effect of those cytokines on β-cell function.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 128
- Patients giving consent to participate the study
- Patients with type 1 diabetes according to WHO definiton
- Acute and chronic inflammatory diseases,
- significant concomitant diseases which may interfere with glucose metabolism
- cancers,
- hemoglobinopathies,
- recently received antibiotics,
- drugs influencing β-cell function and
- insulin sensitivity or anti-inflammatory drugs
- recent history of trauma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Roles of interferon gamma, interleukin-2, tumor necrotizan factor alpha in the pathogenesis of type 1 diabetes 3 day
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medeniyet University Goztepe Training and Research Hospital
🇹🇷Istanbul, Turkey