Vitamin D and Type 2 Diabetes - a Cross Sectional Study

Completed

• Conditions: Type 2 Diabetes Mellitus; Hypovitaminosis D

• Registration Number: NCT00695474
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of the study is to describe vitamin D status among patients with type 2 diabetes and to determine the association between serum 25-hydroxyvitamin D and glycemic control, markers of inflammation and blood pressure

Detailed Description

It has been estimated that 1 billion people worldwide have vitamin D deficiency or insufficiency. It is well known that vitamin D deficiency causes osteoporosis, increases the risk of fracture and causes muscle weakness. But there is now evidence that calcium malnutrition and hypovitaminosis D are predisposing conditions for various common chronic diseases such as malignancies (particularly colon, breast and prostate) chronic inflammatory and autoimmune disease (inflammatory bowel disease, multiple sclerosis) as well as metabolic disorders (metabolic syndrome, hypertension).

It has also been reported that vitamin D deficiency may predispose to glucose intolerance, altered insulin secretion and type 2 diabetes mellitus.

The purpose of this study is to determine vitamin D status among type 2 diabetics in our outpatient clinic and examine the relationship between vitamin D status , calcium and phosphorous metabolism, inflammatory markers, glycemic control, blood pressure and lipid profile.

Moreover the patients are asked to answer a questionnaire regarding lifestyle, exercise, sun exposure and food intake.

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2008-06-09
• Study First Submitted QC: 2008-06-09
• Study First Posted: 2008-06-11
• Primary Completion: 2009-04
• Study Completion: 2009-04
• Status Verified: 2009-07
• Last Update Submitted: 2009-07-10
• Last Update Posted: 2009-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Type 2 diabetes mellitus
• Patients of Danish extraction
• Written consent

Exclusion Criteria

• Renal failure (Urea > 12 mmol/l)
• Age < 18 years
• malabsorption

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vitamin D status and its association with inflammation, glycemic control, lipids and blood pressure.	December 08

Secondary Outcome Measures

Name	Time	Method
Lifestyle (exercise, sun exposure, food intake)	December 08