Caffeine and Resistance Training in Older Adults

Not Applicable

• Conditions: Caffeine and Resistance Training

• Registration Number: NCT06618261
• Lead Sponsor: Alberto Pérez-López

Brief Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training.

Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as fatigue perception, mood state, and potential side effects in older adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-14
• Status Verified: 2024-09
• Study First Submitted: 2024-09-09
• Study First Submitted QC: 2024-09-26
• Last Update Submitted: 2024-09-26
• Study First Posted: 2024-09-30
• Last Update Posted: 2024-09-30
• Primary Completion: 2025-07-30
• Study Completion: 2025-07-30

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Age between ≥ 55
• Body mass index (BMI) ≥ 30 kg/m².
• Physically active subjects (>150 min/week of moderate exercise).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
• Participants capable of performing the tests.

Exclusion Criteria

• History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
• Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise within 48 hours prior to the tests.
• Failing to replicate the same food intake on the two experimental days.
• Consuming caffeine after 6 PM on the day prior to training or testing.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Peak power output and time to reach peak power output at different %1RM	Through study completion, an average of 12 weeks	Measuring during bench press and back squat exercises.
Mean velocity at different %1RM	Through study completion, an average of 12 weeks	Measuring bar mean velocity desplacement during bench press and back squat exercises.
Peak velocity at different %1RM	Through study completion, an average of 12 weeks	Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Mean power output at different %1RM	Through study completion, an average of 12 weeks	Measuring during bench press and back squat exercises.
Number of repetitions performed at 65%1RM until task failure	Through study completion, an average of 12 weeks	In bench press and back squat exercises
Bar velocity deplacement performed in 1 set at 65%1RM until task failure	Through study completion, an average of 12 weeks	In bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failure	Through study completion, an average of 12 weeks	In bench press and back squat exercise
Resting Metabolic Rate (RMR)	Through study completion, an average of 12 weeks	Kcal at rest (RMR) using a metabolic chart.
Maximal Fat Oxidation Rate (MFO)	Through study completion, an average of 12 weeks	g/min (MFO) using a metabolic chart.

Secondary Outcome Measures

Name	Time	Method
Fat mass	Through study completion, an average of 12 weeks	Using electrical bioimpedance and untrasound in the quadriceps muscle
Fat-free mass	Through study completion, an average of 12 weeks	Using electrical bioimpedance and untrasound in the quadriceps muscle
Physical activity (METs-min/wk)	Through study completion, an average of 12 weeks	Using IPAQ
Dietary (g/kg of macronutrients)	Through study completion, an average of 12 weeks	Using a 24-total recall
Mood state	Through study completion, an average of 12 weeks	Mood. Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.
Adverse effects	Through study completion, an average of 12 weeks	Adverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort.

Trial Locations

Locations (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá; 🇪🇸 Alcalá de Henares, Spain