The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

Not Applicable

Completed

• Conditions: Exercise-induced Muscle Damage
• Interventions: Other: Ischemic Preconditioning

• Registration Number: NCT01907841
• Lead Sponsor: St Mary's University College

Brief Summary

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

1. Quantify the use of IPC in recovery following EIMD.

2. Identify any effect of IPC during recovery on muscle function

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2013-07-15
• Study First Submitted QC: 2013-07-22
• Study First Posted: 2013-07-25
• Primary Completion: 2013-11
• Study Completion: 2013-11
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-05
• Last Update Posted: 2014-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Physically Active Males

Exclusion Criteria

• Muscular skeletal disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ischemic Preconditioning	Ischemic Preconditioning	IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.
Ischemic Preconditioning Placebo	Ischemic Preconditioning	Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle

Primary Outcome Measures

Name	Time	Method
Change from baseline in maximal voluntary contraction	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition.; The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.

Secondary Outcome Measures

Name	Time	Method
Change from baseline in Creatine kinase	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser.; The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions
Change from baseline in Limb girth	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position.; The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions
Change from baseline in Muscle soreness	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful).; The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions
Chnage from baseline in Vertical jump	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally.; The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions

Trial Locations

Locations (1)

St Marys Umiversity College; 🇬🇧 London, United Kingdom