Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Single cell RNAseq transcriptomic analysis of skin
研究概览
简要总结
The pathophysiology of systemic sclerosis (SSc) is still poorly understood and there are no effective treatments for this disease. SSc is a heterogeneous disease with varying severity. The heterogeneity of fibroblast profiles, observed in other fibrosing pathologies, has never been thoroughly explored in the skin of SSc patients. The immune system, and in particular B lymphocytes, plays a central role in the pathophysiology of SSc. The interactions between B lymphocytes and the cells responsible for excess collagen production, i.e. fibroblasts, are not fully elucidated The main objective is to analyze the heterogeneity of fibroblasts and infiltrating immune cells as well as their molecular signature in the skin of patients with SSc
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Man or woman over 18 years of age
- •With a systemic sclerosis meeting the ACR-EULAR 2013 criteria Having signed an informed consent
- •Being insured
排除标准
- •Syndrome of overlap with another connective tissue disease according to the international diagnostic criteria
- •Immunosuppressive treatment within 12 months
- •Dosage of current corticosteroid therapy ≥10mg/d
- •Protected minors or adults
- •Pregnant or breastfeeding women
- •Deprived of their liberty
- •Persons in emergency situations
- •Persons who have refused or are unable to give informed consent
结局指标
主要结局
Single cell RNAseq transcriptomic analysis of skin
时间窗: At inclusion
次要结局
- Single cell RNAseq transcriptomic analysis of the whole blood(At inclusion)