Prediction of Survival in Colorectal Cancer Patients on the Basis of Body Mass Index and Lymph Node Yield - a Retrospective Single Center Cohort Analysis Over a Quarter of a Century
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- The Aim of This Study is to Determine the Influence of BMI and Lymph Node Status on OS in CRC Patients in the Long Term
- Sponsor
- Klinikum Floridsdorf
- Enrollment
- 1192
- Locations
- 1
- Primary Endpoint
- overall survival
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Background and aim: Colorectal Cancer (CRC) is one of the most frequent cancer entities in the western world. It is known that obesity is one of the major risk factors for CRC. In contrast, mild obesity seems to have a positive effect on postoperative outcome, which is known as the "obesity paradox". Also, the number of resected lymph nodes (LN) during surgery is very important for correct staging. The aim of the present project is to evaluate the impact of BMI and LN-yield on long term overall survival (OS) of CRC patients treated with curative intent.
Methods: Patients treated for CRC between 1998 and 2011 at the Klinik Favoriten in Vienna, Austria were analyzed in this retrospective single-center cohort analysis concerning OS.
Investigators
Dr. Tamara Braunschmid
MD
Klinikum Floridsdorf
Eligibility Criteria
Inclusion Criteria
- •colorectal carcinoma
- •treated at the Klinik Favoriten between 1998 and 2011
- •elective or acute surgical setting
- •curative intent
- •older than 18 years
Exclusion Criteria
- •other carcinoma (anal, metastases, ...)
- •treated before 1998 or after 2011
- •palliative intent
- •younger than 18 years
Outcomes
Primary Outcomes
overall survival
Time Frame: median follow up of 11.3 years
The aim of the present project is to evaluate the impact of BMI and LN-yield on long term overall survival (OS) of CRC patients treated with curative intent.