One Year Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment-A Prospective,Multicenter,Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12,043
- 试验地点
- 19
- 主要终点
- incidence rate of heart failure
研究概览
简要总结
The main purpose of this study is to build a multi-center, prospective and regionally representative acute myocardial infarction(AMI) cohort，and build a study platform for heart failure caused by AMI; To explore the 1 year incidence rate of heart failure after AMI given the optimized treatment and the treatment model affecting the incidence rate of heart failure, and finally to reduce the incidence rate of heart failure by 5%.
详细描述
the study aim to enroll 12000 acute myocardial infartion (AMI) patients, including ST-segment elevation myocardial infarction (STEMI) and non ST-segment elevation myocardial infarction (NSETMI), Patients were divided into two groups(optimized group and un-optimized group) according to treatment models they accepted in 20 reginally representative hosptials of China. whether optimizaed or not is judged by 4 four aspects,including emergency treatment procedure, pre-infusion medication, reperfusion strategy selection, and early rehabilitation after reperfusion.Patients were followed at 1 month, 6 months and 12 months. The physical condition and clinical events(heart failure, death, re-infarction, revascularization, apoplexy, malignant arrhythmias, bleeding events, other adverse events)were collected at follow up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age≥18 years
- •diagnosed acute myocardial infarction
- •signed the informed consent form
排除标准
- •AMI is caused by surgery, trauma, gastrointestinal bleeding or complications of PCI;
- •AMI occurred in patients who have been hospitalized for other reasons;
- •patients with previous history of chronic heart failure;
- •researchers judging that patient's compliance was poor and could not complete the study according to the requirements.
- •life expectancy is less than 12 months;
- •heart transplant patients;
- •patients with tumors;
结局指标
主要结局
incidence rate of heart failure
时间窗: 12th month after diacharge
incidence rate of heart failure of acute myocardial infarction at 12th month
次要结局
- MACCE rate(12th month after diacharge)
- bleeding rate(12th month after diacharge)
- severe adverse drug reactions(12th month after diacharge)
研究者
Yu Bo
director
Harbin Medical University