The influence of painkillers on ventilation when combined with alcohol
- Conditions
- Opioid induced respiratory depression
- Registration Number
- NL-OMON21263
- Lead Sponsor
- eiden University Medical Centre
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy subjects
a. aged 18-40 years (phase I)
Exclusion Criteria
1. Current diagnosis or history of psychiatric disease.
2. Elderly volunteers should have no cognitive impairment defined as a Mini Mental State Examination (MMSE) score: < 28.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A shift of the Vi-CO2 response curves measured pre-dose, during alcohol clamp, two times after adminstration of oxycodone and comcomitant administration of alcohol and one after discontinuation of alcohol administration
- Secondary Outcome Measures
Name Time Method 1. To assess whether sedation as measured by VAS scale and BIS monitoring is increased in the alcohol conditions compared to the no alcohol condition.<br /><br>2. To asess whether anagelsia induceed by oxycodone is affected by alcohol.<br />