TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants
Not Applicable
Recruiting
- Conditions
- Motor Learning
- Interventions
- Device: Transcranial magnetic stimulationOther: Mental trainingDevice: Robotic armDevice: WristDevice: Peripheral Nerve StimulationDevice: Transcranial direct current stimulationOther: Physical trainingDevice: Paired Associative StimulationDevice: Cervicomedullar stimulation
- Registration Number
- NCT04784832
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 556
Inclusion Criteria
- Male or female between 18 and 60 years old
- Having given written informed consent
- Affiliated to a social security scheme
Exclusion Criteria
- History of psychiatric illness (declarative)
- Person under guardianship, curatorship, safeguard of justice
- Neurological problem that could bias the results of the study (declarative)
- Personal or family history of epilepsy
- Person deprived of liberty by judicial or administrative decision
- Person hospitalized without consent and not subject to legal protection, and person admitted to a health or social institution for purposes other than that of the research
- Person subject to an exclusion period for another research
- Pregnant women or women of childbearing age not using known contraception
- Breastfeeding women
- Person on medication that could influence neurophysiological measures (neuroleptics, anxiolytics, antidepressants)
- Person carrying :
- pacemaker or other device that could interfere with the magnetic field
- Implants (mechanical or electronic: cochlear implants, neural or cardiac pacemakers, infusion pumps, magnetic aneurysm clips, etc.)
- Metallic foreign bodies in the eye or nervous system
- Metallic objects (tattoos, piercings, etc.)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Sequence 1 - Training with same task - Short follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training Sequence 1 - Training with muscle contractions - Long follow-up Mental training Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Training with same task - Long follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training Sequence 1 - Training with different tasks - Long follow-up Mental training Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Training with muscle contractions - Short follow-up Mental training Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training Sequence 2 - Physical training with perturbation during preparation - Long follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation during preparation - Long follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation after preparation - Long follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 1 - Training with same task - Long follow-up Mental training Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training Sequence 1 - Training with different tasks - Short follow-up Transcranial magnetic stimulation Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training Sequence 2 - Physical training with perturbation during preparation - Long follow-up Physical training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation during preparation - Short follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 1 - Training with same task - Short follow-up Mental training Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training Sequence 1 - Training with different tasks - Short follow-up Mental training Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Training with muscle contractions - Long follow-up Transcranial magnetic stimulation Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Training with muscle contractions - Short follow-up Transcranial magnetic stimulation Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Training with different tasks - Long follow-up Transcranial magnetic stimulation Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training Sequence 1 - Control Transcranial magnetic stimulation Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training Sequence 2 - Physical training with perturbation after preparation - Long follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Mental training with perturbation during preparation - Long follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 3 - Training (same task) - Long follow-up Paired Associative Stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (same task) - Long follow-up Cervicomedullar stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (same task) - Short follow-up Cervicomedullar stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 1 Mental training Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 4 - Immobilization - Short follow-up Wrist Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 4 - Immobilization - Short follow-up Mental training Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 2 - Physical training with perturbation after preparation - Short follow-up Physical training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Mental training with perturbation during preparation - Long follow-up Mental training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation during preparation - Short follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation after preparation - Long follow-up Mental training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation after preparation - Short follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation after preparation - Short follow-up Mental training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 3 - Training (same task) - Long follow-up Mental training Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (same task) - Short follow-up Transcranial magnetic stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Short follow-up Paired Associative Stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Short follow-up Cervicomedullar stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Short follow-up Mental training Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 1 Transcranial magnetic stimulation Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 2 - Physical training with perturbation during preparation - Short follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation during preparation - Short follow-up Physical training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation after preparation - Long follow-up Physical training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Physical training with perturbation after preparation - Short follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Mental training with perturbation after preparation - Long follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation after preparation - Long follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 3 - Training (same task) - Short follow-up Peripheral Nerve Stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (same task) - Short follow-up Paired Associative Stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Long follow-up Cervicomedullar stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Long follow-up Paired Associative Stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 2 - Physical training with perturbation after preparation - Short follow-up Robotic arm Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training Sequence 2 - Mental training with perturbation during preparation - Short follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 3 - Training (same task) - Long follow-up Transcranial magnetic stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (same task) - Long follow-up Peripheral Nerve Stimulation Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Long follow-up Peripheral Nerve Stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 1 Cervicomedullar stimulation Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 2 Paired Associative Stimulation Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 4 - Immobilization - Long follow-up Wrist Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 3 - Training (different task) - Short follow-up Transcranial magnetic stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 2 - Mental training with perturbation during preparation - Long follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation during preparation - Short follow-up Mental training Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 2 - Mental training with perturbation after preparation - Short follow-up Transcranial magnetic stimulation Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training Sequence 3 - Training (same task) - Short follow-up Mental training Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Long follow-up Transcranial magnetic stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Long follow-up Mental training Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Training (different task) - Short follow-up Peripheral Nerve Stimulation Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 1 Peripheral Nerve Stimulation Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 4 - Immobilization - Short follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 4 - Immobilization - Long follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 4 - Cathodal - Short follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 3 - Control 2 Transcranial magnetic stimulation Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 3 - Control 2 Peripheral Nerve Stimulation Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 4 - Cathodal - Long follow-up Transcranial direct current stimulation Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Short follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training Sequence 3 - Control 2 Cervicomedullar stimulation Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation Sequence 4 - Immobilization - Long follow-up Mental training Transcranial magnetic stimulation Arm immobilization Motor task Mental training Sequence 4 - Cathodal - Short follow-up Transcranial direct current stimulation Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Control Transcranial magnetic stimulation Transcranial magnetic stimulation Motor task Mental training Sequence 4 - Cathodal - Short follow-up Mental training Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Cathodal - Long follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Control Mental training Transcranial magnetic stimulation Motor task Mental training Sequence 4 - Cathodal - Long follow-up Mental training Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Short follow-up Mental training Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Long follow-up Transcranial magnetic stimulation Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Long follow-up Mental training Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Long follow-up Transcranial direct current stimulation Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training Sequence 4 - Anodal - Short follow-up Transcranial direct current stimulation Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
- Primary Outcome Measures
Name Time Method Evolution of movement accuracy - Sequence 1 Each day in Sequence 1 (Sequence 1 is 11 days) The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
Evolution of maximal deviation - Sequence 2 Each day in Sequence 2 (Sequence 1 is 10 days) The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target
Evolution of movement speed - Sequence 1 Each day in Sequence 1 (Sequence 1 is 11 days) The duration of performed movement sequences
Evolution of trajectory error - Sequence 2 Each day in Sequence 2 (Sequence 1 is 10 days) The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target.
Evolution of final error - Sequence 2 Each day in Sequence 2 (Sequence 1 is 10 days) The distance between the final position of the hand and the position of the final target.
Evolution of movement speed - Sequence 3 Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days) The duration of performed movement sequences
Evolution of movement accuracy - Sequence 3 Each day from day 2 to day 11 of Sequence 3 (Sequence 3 is 11 days) The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
Evolution of movement speed - Sequence 4 Each day in Sequence 4 (Sequence 4 is 6 days) The duration of performed movement sequences
Evolution of movement accuracy - Sequence 4 Each day in Sequence 4 (Sequence 4 is 6 days) The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).
- Secondary Outcome Measures
Name Time Method Evolution of motor evoked potentials amplitude - Sequence 2 Each day in Sequence 2 (Sequence 2 is 10 days) Peak-to-peak amplitude of motor evoked potentials
Evolution of motor evoked potentials amplitude - Sequence 1 Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days). Peak-to-peak amplitude of motor evoked potentials
Evolution of motor evoked potentials amplitude - Sequence 4 Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days) Peak-to-peak amplitude of motor evoked potentials
Evolution of motor evoked potentials amplitude - Sequence 3 Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days) Peak-to-peak amplitude of motor evoked potentials
Trial Locations
- Locations (1)
INSERM - U1093 Cognition, Action, and Sensorimotor Plasticity
🇫🇷Dijon, France