NCT00757029已完成4 期
Association Between Norepinephrine Transporter Polymorphism and Response of Methylphenidate
适应症
干预措施
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Korean ADHD Rating scale-parent version (KARS)
研究概览
简要总结
The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine transporter(SLC6A2). The investigators hypothesis is that norepinephrine transporter polymorphism is associated with responses and adverse effects of OROS-methylphenidate in treatment of ADHD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physically healthy
排除标准
- •Neurological illness
- •Concurrent additional psychiatric treatment
- •Psychotic disorder
- •Major mood disorder needed other psychiatric medication
- •Significant suicidal ideation
- •Pervasive developmental disorder
研究组 & 干预措施
open label
Other
干预措施: norepinephrine transporter polymorphism, (Genetic)
结局指标
主要结局
Korean ADHD Rating scale-parent version (KARS)
时间窗: baseline,1,2,4,8 weeks
次要结局
- Barkely side effect rating scale(1,2,4,8weeks)
研究者
研究点 (1)
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