Targeted Full Energy and Protein Delivery in Critically Ill Patients: A Pilot Randomised Control Trial

Not Applicable

Completed

Conditions: Critical illness
Diet and Nutrition - Other diet and nutrition disorders

Registration Number: ACTRN12615000876594

Lead Sponsor: Royal Melbourne Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 60

Inclusion Criteria

Adutls who are 18 years of Age and Mechanically ventilated for 48hrs, with no plans to extubate

Exclusion Criteria

Patients who have a contraindication to enteral feeding; A limit of medical treatment order in place; Pre-morbid disability causing inability to ambulate > 10m independently (+/- gait aid) Pregnancy; The attending physician does not support inclusion

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The co-primary outcome is the average daily energy and protein delivery between the 2 groups <br>This will be determined by calculating the daily energy and protein delivered from all sources from the fluid balance charts [Daily from enrolment to study day 15 ]

Secondary Outcome Measures

Name	Time	Method
ICU Length of Stay, using hospital records[Day 60];28 day and 60 day mortality and discharge destination [Day 60 ];Muscle Strength - Using handgrip dynamometry and the Medical Research Council (MRC) scale [Baseline, Day 5 and Discharge or day 15];Muscle Mass - Using ultrasound to measure Quadriceps Muscle Layer Thickness (QMLT) bilaterally at two points; the midpoint between the Anterior Superior Iliac Spine (ASIS) and the upper pole of the patella and at the point 2/3 between the ASIS and the top of the patella [Baseline, day 5, day 10 and day 15 or discharge ];Physical function - using the physical function in ICU test score [awakening and discharge or day 15 ];Incidence of ICU -AW (MRC score <48) [Discharge from ICU or study day 15 ]