Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Not Applicable

• Conditions: Acute Kidney Injury
• Interventions: Dietary Supplement: Fructose/glucose/xylitol/saccharose

• Registration Number: NCT04310514
• Lead Sponsor: Medical University of Gdansk

Brief Summary

Rehydration during and after physical exercise is essential to avoid acute kidney injury.

Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.

30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.

Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-03
• Study Start: 2020-03-09
• Study First Submitted: 2020-03-09
• Study First Submitted QC: 2020-03-16
• Last Update Submitted: 2020-03-16
• Study First Posted: 2020-03-17
• Last Update Posted: 2020-03-17
• Primary Completion: 2020-09-01
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age above 18 years
• well-trained soccer players
• informed consent

Exclusion Criteria

• chronic diseases, especially kidney problems
• sigificant changes in urinalysis
• creatinine level above normal values

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Experimental: glucose - fructose - xylitol - saccharose	Fructose/glucose/xylitol/saccharose	* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: fructose - glucose - saccharose - xylitol	Fructose/glucose/xylitol/saccharose	* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: xylitol - saccharose - glucose - fructose	Fructose/glucose/xylitol/saccharose	* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: saccharose - xylitol - fructose - glucose	Fructose/glucose/xylitol/saccharose	* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)

Primary Outcome Measures

Name	Time	Method
Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise	after 60-90 min of pysical exercise
Changes in fractional uric acid excretion	after 60-90 min of pysical exercise

Trial Locations

Locations (1)

Medical University of Gdansk; 🇵🇱 Gdańsk, Poland