Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Medical University of Gdansk
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise
Study Overview
Brief Summary
Rehydration during and after physical exercise is essential to avoid acute kidney injury.
Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.
30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.
Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Diagnostic
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age above 18 years
- •well-trained soccer players
- •informed consent
Exclusion Criteria
- •chronic diseases, especially kidney problems
- •sigificant changes in urinalysis
- •creatinine level above normal values
Arms & Interventions
Experimental: glucose - fructose - xylitol - saccharose
- glucose 35 g (500ml of 7% solution);
- fructose 35 g (500ml of 7% solution);
- xylitol 35 g (500ml of 7% solution);
- saccharose 35 g (500ml of 7% solution)
Intervention: Fructose/glucose/xylitol/saccharose (Dietary Supplement)
Experimental: fructose - glucose - saccharose - xylitol
- glucose 35 g (500ml of 7% solution);
- fructose 35 g (500ml of 7% solution);
- xylitol 35 g (500ml of 7% solution);
- saccharose 35 g (500ml of 7% solution)
Intervention: Fructose/glucose/xylitol/saccharose (Dietary Supplement)
Experimental: xylitol - saccharose - glucose - fructose
- glucose 35 g (500ml of 7% solution);
- fructose 35 g (500ml of 7% solution);
- xylitol 35 g (500ml of 7% solution);
- saccharose 35 g (500ml of 7% solution)
Intervention: Fructose/glucose/xylitol/saccharose (Dietary Supplement)
Experimental: saccharose - xylitol - fructose - glucose
- glucose 35 g (500ml of 7% solution);
- fructose 35 g (500ml of 7% solution);
- xylitol 35 g (500ml of 7% solution);
- saccharose 35 g (500ml of 7% solution)
Intervention: Fructose/glucose/xylitol/saccharose (Dietary Supplement)
Outcomes
Primary Outcomes
Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise
Time Frame: after 60-90 min of pysical exercise
Changes in fractional uric acid excretion
Time Frame: after 60-90 min of pysical exercise
Secondary Outcomes
No secondary outcomes reported
Investigators
Wojciech Wolyniec
Principal Investigator
Medical University of Gdansk