Surgical Stress Measured by Microdialysis
- Conditions
- Trauma
- Interventions
- Procedure: Posterolateral lumbar fusion surgery
- Registration Number
- NCT01495143
- Lead Sponsor
- Northern Orthopaedic Division, Denmark
- Brief Summary
Paraspinal muscle damage is inevitable during conventional posterior lumbar fusion surgery. Minimal invasive surgery is postulated to result in less muscle damage and better outcome. The aim of this study is to monitor metabolic changes of the paraspinal muscle and to evaluate paraspinal muscle damage during surgery using microdialysis (MD).
- Detailed Description
Posterior approach is a common and important surgical procedure for various lumbar diseases. Owing to the anatomy, the damage of paraspinal muscle is inevitable during conventional posterior lumbar fusion surgery. Degeneration and malfunction of the paraspinal muscle might associate with pain and inferior postoperative clinical outcome.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Surgery group Posterolateral lumbar fusion surgery Two MD catheters is placed in the paraspinal muscle at the level of midpoint of incision bilaterally. A reference catheter is placed in the deltoid muscle. Healthy group Posterolateral lumbar fusion surgery Eight healthy volunteers (five males and three females) with a body mass index of 23.8 and without chronic metabolic disease or low back pain. They are all non-smokers and non-medicated.
- Primary Outcome Measures
Name Time Method The glycerol concentration Two hours To study whether the glucerol concentration can be used to evaluate surgery related paraspinal muscle damage
- Secondary Outcome Measures
Name Time Method