Is COPD a Risk Factor for Cardiovascular Disease?

Completed

• Conditions: Chronic Obstructive Pulmonary Disease

• Registration Number: NCT02162095
• Lead Sponsor: University of Zurich

Brief Summary

Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.

Detailed Description

Patients with chronic obstructive pulmonary disease (COPD) suffer from significant cardiovascular morbidity and mortality. Coronary artery disease has often been linked causally to COPD, but the exact pathophysiological mechanisms underpinning this association remain speculative. A retrospective case-control study matching COPD patients and controls one to one for smoking history and conventional cardiovascular risk factors will be performed to study the association between COPD and cardiovascular outcomes. Filling in this knowledge gap may contribute to the understanding of the interplay between COPD and cardiovascular disease.

The objective of this retrospective case-control study is to determine whether COPD might be a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and major adverse cardiovascular events independent of conventional cardiovascular risk factors.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-06-06
• Study First Submitted QC: 2014-06-10
• Study First Posted: 2014-06-12
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-02
• Last Update Posted: 2015-06-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 162

Inclusion Criteria

• SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.2013.
• Coronary artery calcium score and left ventricular ejection fraction data available.
• History of smoking (smoker or ex-smoker).
• COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC < 0.7).
• Control group: Exclusion of chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC > 0.7).

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Exclusion Criteria

• Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation.
• Known congenital or structural heart disease.
• Previous heart transplantation.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary calcium score in cardiac computed tomography	Up to one month	Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.

Secondary Outcome Measures

Name	Time	Method
Major adverse cardiovascular events	Up to three months	Follow-up via telephone interview for major adverse cardiovascular events.
Left ventricular ejection fraction in single-photon emission computed tomography	Up to one month	Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.

Trial Locations

Locations (1)

University Hospital Zurich, Pulmonary Division; 🇨🇭 Zurich, Switzerland