Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis

Not Applicable

Completed

• Conditions: Acute Renal Failure
• Interventions: Procedure: Continuous Venovenous Hemodialysis (CVVHD); Procedure: Continuous Venovenous Hemofiltration (CVVH)

• Registration Number: NCT01062984
• Lead Sponsor: University of Chicago

Brief Summary

Acute kidney injury is often treated with the use of continuous renal replacement therapy. Two commonly used treatments are continuous venvenous hemofiltration (CVVH)and continuous venovenous hemodialysis (CVVHD). CVVH uses convective clearance to remove toxins and solutes from the patients circulation, while CVVHD relies on diffusive clearance to remove these same toxins/solutes. This study will evaluate which of these two methods is more effective at clearing the body of waste/solutes.

We hypothesize that renal replacement therapy by either modality (hemodialysis or hemofiltration; CVVHD or CVVH, respectively) using a modern membrane and higher blood flow rates will be associated with similar clearances of both small and middle molecular weight solutes. We further believe that continuous renal replacement therapy using CVVHD will be associated with decreased clotting events and longer hemofilter survival, as well as improved resource utilization (i.e. nursing time, alarms, etc.).

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01
• Study First Submitted: 2010-02-03
• Study First Submitted QC: 2010-02-03
• Study First Posted: 2010-02-04
• Primary Completion: 2015-09
• Study Completion: 2022-10-25
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Age 18 or older and able to sign consent (or surrogate).
• Must have been referred to the inpatient Nephrology consult service for evaluation of acute kidney injury (AKI).
• Expected survival of at least 48 hours.

Exclusion Criteria

• Hemoglobin < 8 g/dl
• Serum potassium ≥6.5 milliequivalents per liter (mEq/L)
• Weight > 120kg.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous Venovenouos Hemodialysis	Continuous Venovenous Hemodialysis (CVVHD)	-
Continuous Venovenous Hemofiltration	Continuous Venovenous Hemofiltration (CVVH)	-

Primary Outcome Measures

Name	Time	Method
To compare the clearance of urea and creatinine by renal replacement therapy (RRT) using continuous venovenous hemofiltration versus continuous venovenous hemodialysis.	48 hours

Secondary Outcome Measures

Name	Time	Method
To compare the clearance cystatin C and inflammatory cytokines (IL-6 and IL-10) by RRT using continuous venovenous hemofiltration versus continuous venovenous hemodialysis.	48 hours

Trial Locations

Locations (1)

University of Chicago; 🇺🇸 Chicago, Illinois, United States