A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals: A Double-blind Randomized Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Erasmus Medical Center
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- Change in Ruminative Response Scale (RRS) score from pre to post training and after two months (follow up 2)
Study Overview
Brief Summary
Dysfunctioning executive functioning, including working memory (WM), is related to rumination. Findings show that working memory capacity (WMC) can be increased by training. The current study explored by means of a double-blind randomized controlled trial whether an adaptive WM training could reduce rumination, anxiety and depression in a sample of 98 depressed and anxious individuals.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 67 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Major depression diagnosis
- •Anxiety diagnosis
Exclusion Criteria
- •Current psychosis
- •Substance abuse
Arms & Interventions
Placebo working memory training
Intervention: Placebo training (Behavioral)
Working memory training
Intervention: Working memory training (Behavioral)
Outcomes
Primary Outcomes
Change in Ruminative Response Scale (RRS) score from pre to post training and after two months (follow up 2)
Time Frame: Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)
Dutch version; Raes, Hermans, \& Eelen, 2003) measures the frequency of self-reported rumination behavior, with answer options ranging from 1 (never) to 4 (always). The total score of the 22 items was used in the analyses.
Secondary Outcomes
- Change in Beck Depression Inventory Second Edition (BDI-II) score from pre to post training and after two months (follow up 2)(Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test))
- Change in State-Trait Anxiety Inventory (STAI) score from pre to post training and after two months (follow up 2)(Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test))
Investigators
Ingmar Franken
Professor
Erasmus Medical Center