A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals

Not Applicable

Completed

• Conditions: Major Depression; Anxiety Disorder
• Interventions: Behavioral: Placebo training; Behavioral: Working memory training

• Registration Number: NCT02119975
• Lead Sponsor: Erasmus Medical Center

Brief Summary

Dysfunctioning executive functioning, including working memory (WM), is related to rumination. Findings show that working memory capacity (WMC) can be increased by training. The current study explored by means of a double-blind randomized controlled trial whether an adaptive WM training could reduce rumination, anxiety and depression in a sample of 98 depressed and anxious individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08
• Primary Completion: 2011-12
• Status Verified: 2014-04
• Study First Submitted: 2014-04-08
• Study First Submitted QC: 2014-04-18
• Last Update Submitted: 2014-04-18
• Study First Posted: 2014-04-22
• Last Update Posted: 2014-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Major depression diagnosis
• Anxiety diagnosis

Exclusion Criteria

• Current psychosis
• Substance abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo working memory training	Placebo training	-
Working memory training	Working memory training	-

Primary Outcome Measures

Name	Time	Method
Change in Ruminative Response Scale (RRS) score from pre to post training and after two months (follow up 2)	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	Dutch version; Raes, Hermans, \& Eelen, 2003) measures the frequency of self-reported rumination behavior, with answer options ranging from 1 (never) to 4 (always). The total score of the 22 items was used in the analyses.

Secondary Outcome Measures

Name	Time	Method
Change in Beck Depression Inventory Second Edition (BDI-II) score from pre to post training and after two months (follow up 2)	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The Beck Depression Inventory - II (BDI-II; Beck, Steer, \& Brown, 1996; Dutch version: Van der Does, 2002) measures the severity of depression symptoms of the last two weeks.
Change in State-Trait Anxiety Inventory (STAI) score from pre to post training and after two months (follow up 2)	Pre training (baseline), post training (4 weeks after baseline, training starts 1 day after baseline) and follow-up (2 months after post-test)	The State-Trait Anxiety Inventory (STAI; Spielberger, Gorsuch, Lushene, Vagg, \& Jacobs, 1983, Dutch version; Van der Ploeg, Defares, \& Spielberger, 1979) measures self-reported anxiety, divided in state anxiety and trait anxiety.

Trial Locations

Locations (1)

Erasmus University Rotterdam; 🇳🇱 Rotterdam, Zuid Holland, Netherlands