Effects of rTMS on Corticomotor Excitability and Balance Performance in Parkinson's Disease

Not Applicable

Recruiting

• Conditions: Motor Cortex; Parkinson Disease; Excitability; Balance; Motor Skills Disorders

• Registration Number: NCT07195773
• Lead Sponsor: Chung Shan Medical University

Brief Summary

The study investigates the effects of repetitive transcranial magnetic stimulation on motor cortex excitability, balance, and motor function in patients with Parkinson's disease. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on motor cortex excitability.

Detailed Description

The study investigates the effects of repetitive transcranial magnetic stimulation on motor cortex excitability, balance, and motor function in patients with Parkinson's disease. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on motor cortex excitability.

Study Timeline

• Study First Submitted: 2024-05-07
• Study Start: 2024-12-16
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-24
• Last Update Submitted: 2025-09-24
• Study First Posted: 2025-09-29
• Last Update Posted: 2025-09-29
• Primary Completion: 2025-10-30
• Study Completion: 2025-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Patients with primary Parkinson's disease
2. Age: 40-85 years
3. Hoehn and Yahr scale (H&Y scale) : I-III
4. Appropriate prescribed medication, and regular intake for more than 2 weeks
5. Can walk more than 10m with or without the use of assistive devices

Exclusion Criteria

1. Any other neurological presentation (Excluding PD)
2. Any neurological surgery that would affect participation in this experiment
3. Orthopedic pathology and Cardiovascular issues
4. MMSE≦24
5. Exercise used for treatment in the last three months
6. Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Cortical excitability	Cortical excitability will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.	Transcranial magnetic stimulation
Motor function	UPDRS-III will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.	UPDRS-III

Secondary Outcome Measures

Name	Time	Method
Dynamic balance	FRT will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.	Functional Reach Test
Functional mobility	TUG will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.	Timed Up and Go test

Trial Locations

Locations (1)

Chung Shan Medical Unirversity; 🇨🇳 Taichung, Southern District, Taiwan