Study of Talabostat and Cisplatin in Advanced Melanoma
- Conditions
- Skin CancerMelanoma
- Registration Number
- NCT00083252
- Lead Sponsor
- Point Therapeutics
- Brief Summary
The purpose of this study is to assess the antitumor activity and safety of the combination of talabostat and cisplatin in patients with metastatic melanoma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- Histologically or cytologically confirmed melanoma that is metastatic (unresectable Stage IV per AJCC 2002)
- Patients with measurable disease defined as at least one measurable index lesion with clearly defined margins
- ECOG Performance Status of 0, 1, or 2
- Expected survival ≥12 weeks
- Written informed consent
- More than 1 prior chemotherapy or biotherapy regimen for metastatic melanoma
- Radiation therapy to >50% of the bone marrow. Patients must not have had prior radiotherapy to index lesions unless they have clearly progressive disease in this site or there is measurable disease outside the area of prior radiation.
- Clinically significant laboratory abnormalities
- Symptomatic CNS metastases
- Any malignancy within the 5 years immediately prior to the first dose of study medication with the exception of basal cell or non-metastatic squamous cell carcinoma of the skin, and carcinoma in-situ of the cervix
- The need for chronic (i.e., >7 days) oral or intravenous corticosteroid therapy
- Any comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol
- Patients who are within 30 days of chemotherapy, radiation therapy, immunotherapy, or other investigational medication for melanoma. Patients must have recovered from all of the side effects of treatment in order to be enrolled.
- Pregnant or lactating women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (13)
University of Colorado Health Sciences Center
🇺🇸Aurora, Colorado, United States
Cancer Center of Florida
🇺🇸Ocoee, Florida, United States
Cancer Institute Medical Group, Inc.
🇺🇸Santa Monica, California, United States
Mary Crowley Medical Research Center
🇺🇸Dallas, Texas, United States
University of Arkansas Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Indiana Hematology Oncology Consultants
🇺🇸Indianapolis, Indiana, United States
New Mexico Cancer Center Alliance
🇺🇸Albuquerque, New Mexico, United States
NYU School of Medicine
🇺🇸New York, New York, United States
Fifth Avenue Medical Healthcare
🇺🇸New York, New York, United States
Carolinas Medical Center
🇺🇸Charlotte, North Carolina, United States
Tyler Cancer Center
🇺🇸Tyler, Texas, United States
Cancer Care Northwest Research
🇺🇸Spokane, Washington, United States
Cancer Center of the Carolinas
🇺🇸Greenville, South Carolina, United States