Normative Values Laser Nociceptive Evoked Potentials Depending on the Age
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential
研究概览
简要总结
Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.
详细描述
Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Neurological history
- •Neuralgia history (> 3 months)
- •Pathology can cause neuropathy (unbalanced thyroid dysfunction, diabetes, kidney failure, chronic hepatitis, HIV ...)
- •Dermatological disorder known type of Lucite or photosensitivity
- •Medical treatment analgesic, psychotropic or anti-epileptic underway
- •Toxic acquired in the last 72 hours (alcohol, cannabis, other toxic ...)
- •Pregnant women
- •Incapacitate to stand still
- •Participation in another biomedical research in the field of pain in the three months prior to inclusion.
研究组 & 干预措施
healthy volunteers
Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations :
- laser stimulations on lower limbs
- laser stimulations cervical
- 20 laser stimulations for each site on the upper limbs
- laser stimulations on face and neck
干预措施: laser stimulations on lower limbs (Device)
healthy volunteers
Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations :
- laser stimulations on lower limbs
- laser stimulations cervical
- 20 laser stimulations for each site on the upper limbs
- laser stimulations on face and neck
干预措施: laser stimulations cervical (Device)
healthy volunteers
Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations :
- laser stimulations on lower limbs
- laser stimulations cervical
- 20 laser stimulations for each site on the upper limbs
- laser stimulations on face and neck
干预措施: 20 laser stimulations for each site on the upper limbs (Device)
healthy volunteers
Healthy volunteers are able to participate to this study. They must not have neurological troubles. They will have different stimulations :
- laser stimulations on lower limbs
- laser stimulations cervical
- 20 laser stimulations for each site on the upper limbs
- laser stimulations on face and neck
干预措施: laser stimulations on face and neck (Device)
结局指标
主要结局
composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential
时间窗: Day 0
次要结局
- detection threshold (mJ/mm2)(Day 0)
- nociceptive threshold (mJ/mm2)(day 0)