Serum Albumin Ratios Can Improve Sepsis Mortality Prediction

Recruiting

• Conditions: Sepsis
• Interventions: Diagnostic Test: serum albumin; Diagnostic Test: C-Reactive Protein; Diagnostic Test: Serum procalcitonin; Drug: Blood Lactate

• Registration Number: NCT06640504
• Lead Sponsor: Benha University

Brief Summary

Sepsis remains a leading cause of mortality in hospitalized patients, despite advancements in critical care. Existing clinical scores for predicting sepsis outcomes often lack generalizability and complexity, hindering accurate risk assessment and timely intervention. This study aimed to evaluate the prognostic performance of serum albumin ratios to C-reactive protein (CRP), procalcitonin (PCT), and lactate in predicting 28-day morbidities and mortality in sepsis patients admitted to surgical ICUs. By incorporating these albumin ratios into clinical decision-making, we hypothesized that clinicians could more accurately identify patients at high risk of adverse outcomes and tailor treatment strategies accordingly.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-30
• Status Verified: 2024-10
• Study First Submitted: 2024-10-11
• Study First Submitted QC: 2024-10-11
• Last Update Submitted: 2024-10-11
• Study First Posted: 2024-10-14
• Last Update Posted: 2024-10-14
• Primary Completion: 2024-11
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients newly admitted to ICU with sepsis or septic shock;
• Patients were free of exclusion criteria.

Exclusion Criteria

• Patients with acute kidney injury;
• Patients with hemorrhagic shock;
• Patients with immunosuppressive or autoimmune disorders;
• Patients suspected to die in ICU.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 1	serum albumin	Patients newly admitted to ICU with sepsis or septic shock with manifestations suggestive of sepsis according to the guidelines of the 3rd International consensus definitions for sepsis and septic shock.
Group 1	C-Reactive Protein	Patients newly admitted to ICU with sepsis or septic shock with manifestations suggestive of sepsis according to the guidelines of the 3rd International consensus definitions for sepsis and septic shock.
Group 1	Serum procalcitonin	Patients newly admitted to ICU with sepsis or septic shock with manifestations suggestive of sepsis according to the guidelines of the 3rd International consensus definitions for sepsis and septic shock.
Group 1	Blood Lactate	Patients newly admitted to ICU with sepsis or septic shock with manifestations suggestive of sepsis according to the guidelines of the 3rd International consensus definitions for sepsis and septic shock.

Primary Outcome Measures

Name	Time	Method
The proportion of patients reported having at least a 50% lower risk of mortality in surgical ICU (measured by the APACHE II Scale) in correlation with blood biomarkers ratio.	1 month	The diagnostic value of blood biomarkers ratio as lactate-to-albumin ratio (LAR), CRP-to-albumin ratio (CAR), and procalcitonin (PCT)-to-albumin ratio (PAR) in decreased sepsis mortality according to APACHE II Scale.

Trial Locations

Locations (1)

Benha University; 🇪🇬 Banhā, El Qalyoubia, Egypt