The immunogenicity of 7-valent pneumococcal conjugate vaccine (PCV-7) in allogeneic bone marrow transplant recipients
Recruiting
- Conditions
- Patient is scheduled to have allogeneic bone marrow transplantation (mathced realted or unrealted) excluding cord transplant.Surgery - Bone
- Registration Number
- ACTRN12605000773639
- Lead Sponsor
- Investigator driven study
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Any patient undergoing allogeneic bone marrow transplantation (mathced related or unrelated) at Westmead Hospital who has not received pneumococcal vaccine wil be eligible.
Exclusion Criteria
Subjects with a history of pneumococcal Vaccination (as determined by self-report and validation by general practitioner records) will be ineligible. Subjects who are thrombocytopaenic or have any other bleeding disorder at the time of vaccination will be ineligible.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare immune response to two different schedules of 7-valent pneumococcal conjugate vaccine (PCV7), followed by boosting with the 23-valent polysaccharide vaccine (PPV) in allogeneic bone marrow transplant/ stem cell transplant (SCT) recipients without a past history of vaccination with PPV.[]
- Secondary Outcome Measures
Name Time Method 1.pneumococcal serotype specific IgG avidity after each dose to assess immunological memory[];2.functional antibody assays using opsonophagocytosis[To be done at 12 months only.];3.antibody response to the carrier protein pre and post vaccination.[]