Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Correlation and consistency analysis between exhaled breath concentrations of two anesthetics and BIS values
研究概览
简要总结
This study aims to propose a strategy for controlling the depth of anesthesia based on continuous and non-invasive monitoring of exhaled breath: BIS value during intravenous-inhalation combined anesthesia is predicted according to the real-time exhaled concentrations of sevoflurane and propofol, so as to achieve the depth of anesthesia management for patients who cannot use standard BIS. Furthermore, the relationship between anesthetic concentration and depth of anesthesia was analyzed in different subgroups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old
- •ASA I-III
- •Expected duration of surgery > 1 hour
- •Radial artery catheterization was performed
- •Patients requiring BIS monitoring.
排除标准
- •Patients with contraindications to general anesthesia
- •mental disorder, unable to answer
- •long-term use of antiepileptic drugs and psychotropic drugs
- •pregnant patients
- •patients refused to participate
- •the investigator thought that the study was not suitable for inclusion
- •patients who did not wake up in PACU
结局指标
主要结局
Correlation and consistency analysis between exhaled breath concentrations of two anesthetics and BIS values
时间窗: 1 day
Correlation and consistency analysis between exhaled breath concentrations of two anesthetics detected by GC-SAW system and BIS values
Establish a 3D drug dose-effect model of the exhaled concentration and BIS value of anesthetics
时间窗: 1day
Establish a 3D drug dose-effect model based on the exhaled gas concentration of anesthetics detected by the GC-SAW system and BIS value
次要结局
- Correlation and consistency analysis of exhaled breath concentration and blood concentration of anesthetics(1day)
- The incidence of adverse reactions(72 hours)