Randomized controlled trial examining the usefulness and safety of midazolam continuous intravenous infusion and pethidine hydrochloride in small intestine endoscope - NHOG-MDZ-GFCF

In this study, we compared the efficacy and safety of "continuous intravenous midazolam plus pethidine hydrochloride" (new group) with those of "intermittent midazolam plus pethidine hydrochloride" (standard group) in small bowel endoscopy. The new group tended to have less body movement, but was not superior to the standard group. Given the acceptable safety profile of both groups and the paucity of similar studies, continuous infusion may be considered an option for sedation in some patient populations.