Modulation of the Intestinal Microbiome, and Its Effects on Endurance Exercise Capacity in Moderately Trained Individuals
试验速览
- 阶段
- 不适用
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Time to Exhaustion
研究概览
简要总结
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
详细描述
The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.
a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks.
Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female 18 - 40 y
- •BMI range 18.5 - 25 kg/m2
- •Recreational active (performing non-competitive physical endurance exercise at least two times per week with a minimum duration of 60 minutes per exercise bout)
排除标准
- •Performing regular resistance training (3+ times per week, carrying out progressive overload training)
- •Subject following an overly imbalanced or restrictive diet as per nutritional advice
- •Participants who received antibiotics in the 90 days prior to the start of the study
- •Self-admitted lactose intolerance
- •Administration of probiotic or prebiotic supplements in the 14 days prior to the study
研究组 & 干预措施
Prebiotic intervention group
Prebiotic supplementation
干预措施: Prebiotic (Dietary Supplement)
Placebo control group
Maltodextrin
干预措施: Placebo (Other)
结局指标
主要结局
Time to Exhaustion
时间窗: From baseline to end of the study (up to max 45 days)
Time on cycle ergometer until exhaustion
次要结局
- Insulin(From baseline to end of the study (up to max 45 days))
- Plasma short chain fatty acids(From baseline to end of the study (up to max 45 days))
- Gut microbiota composition(From baseline to end of the study (up to max 45 days))
- Blood glucose(From baseline to end of the study (up to max 45 days))
- Intestinal permeability by sugar test(From baseline to end of the study (up to max 45 days))
研究者
Fred Troost
Principal Investigator
Maastricht University