Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence
试验速览
- 阶段
- 不适用
- 状态
- 撤回
研究概览
简要总结
The primary objective is to develop a rapid in vitro screening assay for detection of pancreatic cancer biomarkers in blood of patients with pancreatic cancer.
详细描述
The goal of the project is to develop a rapid in vitro screening assay for detection of cancer biomarkers in blood. The aim is testing and optimization of nanoparticle sensors, based on cyanine dyes that are chemically linked to Fe/Fe3O4 nanoparticles via protease-selective consensus (cleavage) sequences. The focus is on the quantitative determination of active cancer-specific proteases in blood via simple fluorescence measurements. The matrix metalloproteinases, urokinase-type plasminogen activator, and cathepsins, are up-regulated in the vast majority of progressing cancers and can, therefore, serve as markers for cell survival/tumor progression, angiogenesis, and tissue remodeling/invasion
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion Criteria for Pancreatic Cancer Patients:
- •Patients will either have a histologic diagnosis of pancreatic carcinoma or a clinical picture consistent with pancreatic cancer and will be undergoing surgery or a diagnostic procedure to confirm the diagnosis.
- •Patients will have had no prior treatment or surgery
- •Inclusion Criteria for Healthy Subjects:
- •Subjects will have no prior history of any cancer
排除标准
- •Exclusion Criteria for Pancreatic Cancer Patients
- •Any prior treatment for pancreatic cancer
- •Poorly controlled diabetes
- •Exclusion Criteria for Healthy Subjects
- •Poorly controlled diabetes