Physical performance and protein energy wasting in patients starting with nocturnal hemodialysis compared to conventional hemodialysis: the DiapriFit study

Completed

• Conditions: malnutrition; nocturnal hemodialysis; 10013296; 10029149

• Registration Number: NL-OMON45059
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

- hemodialysis or hemodiafiltration treatment of more than 3 months, with stable hemodialysis regarding weight, blood pressure, and no active infection.
- for the intervention group consent to switch from conventional hemodialysis 2-3 times/week 3-5 hours, to nocturnal hemodialysis 3-4 times/week 7-9 hours.
- ability to understand the study protocol.
- informed consent.
- age >= 18 years and <= 80 years of age.

Exclusion Criteria

- dementia
- life expectancy < 12 months
- planned renal transplantation within 12 months
- instable angina pectoris
- recent myocardial infarction
- severe pulmonary disease
- treatment incompliance, i.e. non-adherence to dialysis regimen

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary objective:<br /><br>Does the change from conventional hemodialysis to nocturnal hemodialysis lead to<br /><br>improved physical performance?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objective:<br /><br>Does the change from conventional hemodialysis to nocturnal hemodialysis lead to<br /><br>decreased protein energy wasting?</p><br>