Drug utilization study of proton pump inhibitors in patients with acid reflux disorder in tertiary care hospital

Proton pump inhibitors (PPIs) are very effective drugs that drastically lower gastric acid output

by permanently blocking the gastric H+/K+ ATPase enzyme, which is found in the stomach’s

parietal cells. They stand in for the key component of treatment for acidpeptic

conditions such as GERD, peptic ulcer disease, Zollinger- Ellison syndrome, and for

preventing stress-induced mucosal bleeding in patients in critical condition? Due to their abilit y

to suppress acid quickly and effectively compared to H2-receptor antagonists, PPIs are now

one of the most often prescribed medication classes globally Despite the widespread use of PPIs, there remains a knowledge gap regarding the

appropriateness of their prescription in hospital settings, particularly in relation to GERD

management. Comprehensive evaluation of prescribing practices in such a context is crucial

for ensuring that patients receive therapy in alignment with evidence-based recommendatio ns.

Furthermore, understanding the trends in PPI utilization can provide useful information for

physicians, pharmacists, and policymakers to design interventions aimed at improving rational

prescribing.