Assessment of Fluid Responsiveness With Carotid Flow Change During General Anaesthesia

Medical University of Warsaw1 site in 1 country61 target enrollmentOctober 22, 2018

ConditionsAnesthesia Fluid Responsiveness

Overview

Phase: N/A
Intervention: Not specified
Conditions: Anesthesia
Sponsor: Medical University of Warsaw
Enrollment: 61
Locations: 1
Primary Endpoint: Change in cardiac output
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care. Reliability of several invasive measurements used for this purpose for many years have been questioned recently. The study will evaluate consistency between carotid artery flow derivatives and standard haemodynamic measurement (LIDCO rapid) in navigation of intraoperative fluid therapy.

Registry

clinicaltrials.gov

Start Date

October 22, 2018

End Date

March 30, 2019

Last Updated

6 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Medical University of Warsaw

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Major abdominal surgery
•Artery catheter required

Exclusion Criteria

•Laparoscopic surgery
•Known history of carotid endarterectomy
•Known history of carotid stenosis
•Non-sinus rhythm
•Systolic or diastolic heart failure
•Chronic kidney disease
•Pulmonary hypertension
•Carotid artery anomaly
•Unable to visualise carotid artery
•Angle of correction \> 60

Outcomes

Primary Outcomes

Change in cardiac output

Time Frame: Before and 2 minutes after intervention

A measure of change of scaled cardiac output (nCO) with LiDCO device

Change in a corrected carotid artery flow

Time Frame: Before and 2 minutes after intervention

Ultrasound measure of corrected carotid artery flow time

Secondary Outcomes

Change in a carotid blood flow(Before and 2 minutes after intervention)
Change in stroke volume variation(Before and 2 minutes after intervention)
Change in pulse pressure variation(Before and 2 minutes after intervention)
Change in the maximal systolic carotid velocity variation(Before and 2 minutes after intervention)
Change in a velocity time integral of carotid flow(Before and 2 minutes after intervention)