Assessment of Fluid Responsiveness With Carotid Flow Change During General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Change in cardiac output
研究概览
简要总结
Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care. Reliability of several invasive measurements used for this purpose for many years have been questioned recently. The study will evaluate consistency between carotid artery flow derivatives and standard haemodynamic measurement (LIDCO rapid) in navigation of intraoperative fluid therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major abdominal surgery
- •Artery catheter required
排除标准
- •Laparoscopic surgery
- •Known history of carotid endarterectomy
- •Known history of carotid stenosis
- •Non-sinus rhythm
- •Systolic or diastolic heart failure
- •Chronic kidney disease
- •Pulmonary hypertension
- •Carotid artery anomaly
- •Unable to visualise carotid artery
- •Angle of correction > 60
研究组 & 干预措施
Fluid bolus
Patients included in the study will receive fluid bolus.
干预措施: Fluid bolus (Diagnostic Test)
结局指标
主要结局
Change in cardiac output
时间窗: Before and 2 minutes after intervention
A measure of change of scaled cardiac output (nCO) with LiDCO device
Change in a corrected carotid artery flow
时间窗: Before and 2 minutes after intervention
Ultrasound measure of corrected carotid artery flow time
次要结局
- Change in a carotid blood flow(Before and 2 minutes after intervention)
- Change in stroke volume variation(Before and 2 minutes after intervention)
- Change in pulse pressure variation(Before and 2 minutes after intervention)
- Change in the maximal systolic carotid velocity variation(Before and 2 minutes after intervention)
- Change in a velocity time integral of carotid flow(Before and 2 minutes after intervention)