A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
- Registration Number
- NCT06104124
- Lead Sponsor
- Amgen
- Brief Summary
Primary Objective:
To evaluate the effect of dazodalibep on systemic manifestations of Sjögren's Syndrome (SS) in participants with moderate-to-severe systemic disease activity.
Secondary Objectives:
1. To evaluate the effect of dazodalibep on patient reported outcomes (PROs) in participants with SS.
2. To evaluate the safety and tolerability of dazodalibep in participants with SS
- Detailed Description
Acquired from Horizon in 2024.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 621
- Diagnosed with Sjögren's syndrome (SS) by meeting the 2016 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) Classification Criteria.
- Have an European Alliance of Associations for Rheumatology Sjögren's Syndrome Disease Activity Index (ESSDAI) score of >= 5 despite symptomatic or local therapy at screening.
- Positive for either anti-Ro autoantibodies or rheumatoid factor (RF), or both at screening (as per the central laboratory test).
Key
- Medical history of confirmed deep vein thrombosis, pulmonary embolism, or arterial thromboembolism within 2 years of screening.
- Active malignancy or history of malignancy within the last 5 years, except in situ carcinoma of cervix treated with apparent success with curative therapy > 12 months prior to screening OR cutaneous basal cell carcinoma following presumed curative therapy.
- Individuals with any severe or life-threatening cardiovascular (including vasculitis), respiratory, endocrine, gastrointestinal, hematological, psychiatric, or systemic disorder or any other condition that would place the individual at unacceptable risk of complications, interfere with evaluation of the IP, or confound the interpretation of participant safety or study results.
- Individuals who have a positive test for hepatitis B, hepatitis C, or HIV infection. A positive test for hepatitis B at screening is defined as: (1) positive for HBsAg OR (2) positive for either HBcAb or HBsAb and HBV DNA detected above the LLOQ by reflex testing by the central laboratory at screening.
- Active TB or untreated (per local guidelines) latent TB
- Individuals with a history of more than one episode of herpes zoster and/or any opportunistic infection in the last 12 months, and active infection requiring systemic treatment at the time of screening or through randomization, or history of more than 2 infections requiring intravenous (IV) antibiotics within 12 months prior to screening.
- Individuals who have received a live (attenuated) vaccine within the 4 weeks prior to randomization or plan to receive a live vaccine during their participation in the study.
- Last administration of experimental or investigational biologic or oral agents < 6 months prior to screening.
- Individuals who have had previous treatment with any biologic B-cell-depleting therapy (eg, rituximab, ocrelizumab, inebilizumab, ofatumumab, or ianalumab) within 12 months or other B-cell-targeting therapy (eg, belimumab) < 3 months prior to screening.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dazodalibep Dose 1 Dazodalibep Participants will be administered dose 1 of dazodalibep by intravenous (IV) infusion. Dazodalibep Dose 2 Dazodalibep Participants will be administered dose 2 of dazodalibep by IV infusion. Placebo Placebo Participants will be administered placebo by IV infusion.
- Primary Outcome Measures
Name Time Method Change from baseline in European Alliance of Associations for Rheumatology Sjögren's Syndrome Disease Activity Index (ESSDAI) Score At Week 48
- Secondary Outcome Measures
Name Time Method Proportion of participants achieving ESSDAI response At Week 48 Change from baseline in Diary for Assessing Sjogren's Patient-Reported Outcome Index (DASPRI) dryness domain score At Week 48 Change from baseline in ESSPRI dryness domain score At Week 48 Change from baseline in DASPRI dryness domain score At Week 48 Change from baseline in tender and swollen joint counts At Week 48 Change from baseline in Patient-Reported Outcomes Measurement Information System Fatigue-Short Form 10a (PROMIS-Fatigue-SF-10a) At Week 48 Change from baseline in ESSDAI score Week 12 and Week 24 Change from baseline in DASPRI total score At Week 48 Change from baseline in ESSPRI total score At Week 48 Change from baseline in total stimulated salivary flow At Week 48 Number of participants With Treatment Emergent Adverse Events (TEAEs) Baseline (Day 1) to Week 56 Number of participants With Treatment Emergent Serious Adverse Events (TESAEs) Up to Week 56 Number of participants With Adverse Events of Special Interest (AESIs) Up to Week 56
Trial Locations
- Locations (246)
Arizona Arthritis & Rheumatology Associates - Avondale
🇺🇸Avondale, Arizona, United States
Arizona Research Clinic PLLC
🇺🇸Chandler, Arizona, United States
Arizona Arthritis and Rheumatology Associates - Flagstaff - 399 S Malpais Ln
🇺🇸Flagstaff, Arizona, United States
Arizona Arthritis and Rheumatology Associates - Gilbert - 3645 S Rome St
🇺🇸Gilbert, Arizona, United States
Arizona Arthritis and Rheumatology Associates - Glendale - 5681 W Beverly Ln
🇺🇸Glendale, Arizona, United States
Arizona Arthritis and Rheumatology Associates - Tucson - 2001 W Orange Grove Rd
🇺🇸Tucson, Arizona, United States
UCSD Altman Clinical and Translational Research Institute Building
🇺🇸La Jolla, California, United States
Inland Rheumatology Clinical Trials Incorporated
🇺🇸Upland, California, United States
Tekton Research, LLC - 2121 E Harmony Rd - PPDS
🇺🇸Fort Collins, Colorado, United States
Bradenton Research Center Inc
🇺🇸Bradenton, Florida, United States
Clinical Research of West Florida Inc - Clearwater
🇺🇸Clearwater, Florida, United States
Life Arc Research
🇺🇸Coral Gables, Florida, United States
University of Miami - Leonard M. Miller School of Medicine
🇺🇸Miami, Florida, United States
Suncoast Clinical Research - ATLAS - New Port Richey - PPDS
🇺🇸New Port Richey, Florida, United States
Millennium Research
🇺🇸Ormond Beach, Florida, United States
West Broward Rheumatology Associates, Inc.
🇺🇸Tamarac, Florida, United States
BayCare Medical Group
🇺🇸Tampa, Florida, United States
Augusta University Medical Center-Augusta-1120 15th St
🇺🇸Augusta, Georgia, United States
OrthoIllinois, LTD
🇺🇸Rockford, Illinois, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Shores Rheumatology
🇺🇸Saint Clair Shores, Michigan, United States
Kansas City Physician Partners-8350 N Saint Clair Ave
🇺🇸Kansas City, Missouri, United States
Kirk Kerkorian School of Medicine UNLV
🇺🇸Las Vegas, Nevada, United States
Arthritis, Rheumatic & Bone Disease Associates - P
🇺🇸Voorhees, New Jersey, United States
NYU Langone Health - Joseph S. and Diane H. Steinberg Ambulatory Care Center
🇺🇸Brooklyn, New York, United States
Arthritis and Osteoporosis Consultants of The Carolinas
🇺🇸Charlotte, North Carolina, United States
Duke Early Phase Clinical Research Unit
🇺🇸Durham, North Carolina, United States
Onsite Clinical Solutions, LLC - Salisbury
🇺🇸Salisbury, North Carolina, United States
Arthritis & Osteoporosis Center of Southwest Ohio - Miamisburg
🇺🇸Miamisburg, Ohio, United States
University of Toledo Medical Center
🇺🇸Toledo, Ohio, United States
STAT Research-600 Aviator Ct
🇺🇸Vandalia, Ohio, United States
Low Country Rheumatology PA-Summerville
🇺🇸Summerville, South Carolina, United States
West Tennessee Research Institute
🇺🇸Jackson, Tennessee, United States
Murfreesboro Medical Clinic Westlawn
🇺🇸Murfreesboro, Tennessee, United States
Amarillo Center For Clinical Research - ClinEdge - PPDS
🇺🇸Amarillo, Texas, United States
Tekton Research, LLC - W Gate Blvd - Austin - PPDS
🇺🇸Austin, Texas, United States
Accurate Clinical Management-Baytown
🇺🇸Baytown, Texas, United States
Precision Comprehensive Clinical Research Solutions
🇺🇸Grapevine, Texas, United States
Prolato Clinical Research Center
🇺🇸Houston, Texas, United States
R & H Clinical Research-777 S Fry Rd
🇺🇸Katy, Texas, United States
Valley Arthritis Center
🇺🇸McAllen, Texas, United States
University of Texas - San Antonio - Health Science Center - PPDS
🇺🇸San Antonio, Texas, United States
DM Clinical Research - Migraine and COPD - PPDS
🇺🇸Tomball, Texas, United States
Metrodora Institute
🇺🇸West Valley City, Utah, United States
Overlake Arthritis & Osteoporosis Center
🇺🇸Bellevue, Washington, United States
Western Washington Medical Group, Bothell - Rheumatology
🇺🇸Bothell, Washington, United States
Rheumatology and Pulmonary Clinic
🇺🇸Beckley, West Virginia, United States
Sanatorio Agote - Swiss Medical Group - PPDS
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Sanatorio Guemes
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Framingham Centro Médico
🇦🇷La Plata, Buenos Aires, Argentina
Instituto CER S.A.
🇦🇷Quilmes, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Quilmes SRL
🇦🇷Quilmes, Buenos Aires, Argentina
MR Medicina Reumatologica
🇦🇷San Fernando, Buenos Aires, Argentina
Hospital General de Agudos Dr. José María Ramos Mejia
🇦🇷Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires, Argentina
Expertia S.A- Mautalén Salud e Investigación
🇦🇷Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires, Argentina
Centro Privado de Medicina Familiar
🇦🇷Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires, Argentina
Consultorios Médicos Dr. Doreski - PPDS
🇦🇷Ciudad Autónoma de Buenos Aires, Ciudad Autónoma De BuenosAires, Argentina
Sanatorio Allende S.A
🇦🇷Ciudad De Cordoba, Córdoba, Argentina
Centro de Investigaciones Médicas Tucumán - PPDS
🇦🇷San Miguel de Tucuman, Tucumán, Argentina
Centro de Investigaciones Reumatológicas
🇦🇷San Miguel De Tucumán, Tucumán, Argentina
Clínica Mayo de U.M.C.B. S.R.L
🇦🇷San Miguel De Tucumán, Tucumán, Argentina
DOM Centro de Reumatología
🇦🇷Buenos Aires, Argentina
Aprillus Asistencia e Investigacion de Arcis Salud SRL
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro Medico Arsema
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro Polivalente de Asistencia e Investigación Clínica - CER San Juan
🇦🇷San Juan, Argentina
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
UZ Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
UZ Leuven
🇧🇪Leuven, Vlaams Brabant, Belgium
SER - Serviços Especializados em Reumatologia da Bahia S/S - ME
🇧🇷Salvador, Bahia, Brazil
Centro de Estudos em Terapias Inovadoras
🇧🇷Curitiba, Paraná, Brazil
Irmandade da Santa Casa de Misericórdia de Belo Horizonte - PPDS
🇧🇷Belo Horizonte, Minas Gerais, Brazil
LMK Servicos Medicos SS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centre de Recherche Musculo-Squelettique - 1920 Rue Bellefeuille
🇨🇦Trois Rivieres, Quebec, Canada
Centro de especialidades médicas Vanguardia
🇨🇱Temuco, Araucanía, Chile
Clinical Research Chile SpA - PPDS
🇨🇱Valdivia, Los Ríos, Chile
Enroll SpA - Dr. Manuel Barros Borgono - PPDS
🇨🇱Providencia, Región-MetropolitanadeSantiago, Chile
BIOCINETIC Ltda
🇨🇱Santiago, Región-MetropolitanadeSantiago, Chile
Centro de Investigacion de Enfermedades Respiratorias e inmunologicas
🇨🇱Vina del Mar, Valparaíso, Chile
Clinical Center Zagreb - Oncology - Salata 7 - PPDS
🇭🇷Zagreb, Grad Zagreb, Croatia
Clinical Hospital Sveti Duh
🇭🇷Zagreb, Grad Zagreb, Croatia
Poliklinika Bonifarm-Hondlova 2/10
🇭🇷Zagreb, Grad Zagreb, Croatia
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
University Hospital of Split-Spinciceva 1
🇭🇷Split, Croatia
Odense Universitets Hospital
🇩🇰Odense C, South Denmark, Denmark
Hopital Emile Muller
🇫🇷Mulhouse, Haut-Rhin, France
CHU de Saint-Etienne - Hôpital Nord
🇫🇷Saint-Priest-en-Jarez, Loire, France
CHU de Bordeaux - Hôpital Saint-André
🇫🇷Bordeaux, France
CHU de Brest - Hôpital La Cavale Blanche
🇫🇷Brest, France
AP-HP - Hôpital Bicêtre
🇫🇷Le Kremlin-Bicêtre, France
AP-HP - Hôpital Saint Antoine
🇫🇷Paris, France
Hôpitaux Universitaires de Strasbourg
🇫🇷Strasbourg, France
University Clinic Heidelberg
🇩🇪Heidelberg, Baden-Württemberg, Germany
Rheumazentrum Prof. Dr. med. Gunther Neeck-Standort Bad Doberan
🇩🇪Bad Doberan, Mecklenburg-Vorpommern, Germany
Rheumazentrum Greifswald
🇩🇪Greifswald Hansestadt, Mecklenburg-Vorpommern, Germany
DRK Gemeinnützige Krankenhaus GmbH Sachsen - DRK Krankenhaus Chemnitz-Rabenstein
🇩🇪Chemnitz, Germany
MVZ Rheuma
🇩🇪Hamburg, Germany
Olympion General Clinic-Duplicate
🇬🇷Patra, Achaïa, Greece
Naval Hospital of Athens
🇬🇷Athina, Attiki, Greece
Laiko General Hospital of Athens
🇬🇷Athina, Attiki, Greece
General Hospital ''Asklepieio Voulas''
🇬🇷Voula, Attiki, Greece
University General Hospital of Larissa
🇬🇷Larissa, Larisa, Greece
Euromedica Kianous Stavros
🇬🇷Thessaloniki, Greece
Bekes Varmegyei Kozponti Korhaz
🇭🇺Gyula, Békés, Hungary
Vasarhelyi Sarkanyfu Kft.
🇭🇺Hódmezővásárhely, Csongrád, Hungary
Debreceni Egyetem Klinikai Kozpont Nagyerdei Campus
🇭🇺Debrecen, Hajdú-Bihar, Hungary
Del-pesti Centrumkorhaz- Orszagos Hematologiai és Infektologiai Intezet - Szent Laszlo Korhaz Teleph
🇭🇺Budapest, Hungary
Meir Medical Center
🇮🇱Kfar Sava, HaMerkaz, Israel
Hadassah Medical Center- Ein Kerem - PPDS
🇮🇱Jerusalem, Yerushalayim, Israel
The Chaim Sheba Medical Center - PPDS
🇮🇱Ramat Gan, Israel
AUSL di Reggio Emilia - IRCCS - Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Emilia-Romagna, Italy
Azienda Sanitaria Universitaria Friuli Centrale - PO Universitario Santa Maria della Misericordia
🇮🇹Udine, Friuli-Venezia Giulia, Italy
Fondazione Policlinico Universitario Campus Bio-Medico
🇮🇹Roma, Lazio, Italy
Fondazione Policlinico Universitario A Gemelli - Rome - PPDS
🇮🇹Roma, Lazio, Italy
ASST Gaetano Pini - Presidio Ospedaliero Gaetano Pini
🇮🇹Milano, Lombardia, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Lombardia, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
🇮🇹Novara, Piemonte, Italy
A.O.U. Città della Salute e della Scienza di Torino
🇮🇹Torino, Piemonte, Italy
AOU Policlinico Gaspare Rodolico-San Marco - Presidio Ospedaliero San Marco
🇮🇹Catania, Sicilia, Italy
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Toscana, Italy
Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara
🇮🇹Pisa, Toscana, Italy
Azienda Ospedaliera Universitaria Integrata Di Verona
🇮🇹Verona, Veneto, Italy
San Paolo Hospital Civitavecchia
🇮🇹Civitavecchia RM, Italy
Chubu Rosai Hospital
🇯🇵Nagoya-Shi, Aiti, Japan
Japan Community Health Care Organization (JCHO) Chukyo Hospital
🇯🇵Nagoya-Shi, Aiti, Japan
Daido Clinic
🇯🇵Nagoya, Aiti, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo-Shi, Hokkaidô, Japan
Hokkaido University Hospital
🇯🇵Sapporo-Shi, Hokkaidô, Japan
Hospital of the University of Occupational and Environmental Health, Japan
🇯🇵Kita Kyushu-shi, Hukuoka, Japan
Hyogo Medical University Hospital
🇯🇵Nishinomiya-Shi, Hyôgo, Japan
University of Tsukuba Hospital
🇯🇵Tsukuba-Shi, Ibaraki, Japan
Kanazawa Medical University Hospital
🇯🇵Kahoku-Shi, Isikawa, Japan
Kanazawa University Hospital
🇯🇵Kanazawa-shi, Isikawa, Japan
National Hospital Organization Yokohama Medical Center
🇯🇵Yokohama-Shi, Kanagawa, Japan
University Hospital, Kyoto Prefectural University of Medicine
🇯🇵Kyoto-Shi, Kyôto, Japan
Kyoto University Hospital
🇯🇵Kyoto-Shi, Kyôto, Japan
Nagasaki University Hospital
🇯🇵Nagasaki-shi, Nagasaki, Japan
Sasebo Chuo Hospital
🇯🇵Sasebo-Shi, Nagasaki, Japan
Kurashiki Medical Clinic
🇯🇵Kurashiki-Shi, Okayama, Japan
Saitama Medical University Hospital
🇯🇵Iruma-gun, Saitama, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu-city, Sizuoka, Japan
Nippon Medical School Hospital
🇯🇵Bunkyo-Ku, Tokyo, Japan
St. Luke's International Hospital
🇯🇵Chuo-Ku, Tokyo, Japan
Nihon University Itabashi Hospital
🇯🇵Itabashi, Tokyo, Japan
Tokyo Medical Center
🇯🇵Meguro-Ku, Tokyo, Japan
Keio University Hospital
🇯🇵Shinjuku-Ku, Tokyo, Japan
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Centro de Investigación en Artritis y Osteoporosis - PPDS
🇲🇽Mexicali, Baja California, Mexico
The Catholic University of Korea, Seoul St Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon-si, Korea, Republic of
Mediadvance Clinical S.A.P.I. de C.V.
🇲🇽Parques De San Felipe, Chihuahua, Mexico
ONCOR - Centro de Infusion e Investigación Oncologia de Saltillo S.C
🇲🇽Saltillo, Coahuila, Mexico
Centro de Investigación y Tratamiento Reumatológico S.C
🇲🇽San Miguel Chapultepec, Distrito Federal, Mexico
CIMAB SA de CV
🇲🇽Torreón Centro, Coahuila, Mexico
Cryptex Investigación Clínica, S.A. de C.V.
🇲🇽Ciudad de México, Distrito Federal, Mexico
Centro de Estudios de Investigacion Basica Y Clinica SC
🇲🇽Guadalajara, Jalisco, Mexico
Bioclinica - Centro Integral En Reumatologia Sociedad Anónima de Capital Variable - PPDS
🇲🇽Guadalajara, Jalisco, Mexico
Unidad de Atencion Medica e Investigacion en Salud
🇲🇽Merida, Yucatán, Mexico
Centro de Investigacion Farmacologica Del Bajio Sc
🇲🇽Leon, Mexico
Consultorio de Reumatologia
🇲🇽Mexico, Mexico
Clinstile, S.A. de C.V.
🇲🇽Mexico, Mexico
Hospital Universitario Dr. Jose Eleuterio Gonzalez
🇲🇽Mitras Centro, Mexico
Accelerium, S. de R.L. de C.V. - PPDS
🇲🇽Monterrey, Mexico
Oaxaca Site Management Organization - Clinic - OSMO - PPDS
🇲🇽Oaxaca, Mexico
Optimal Clinical Trials Ltd - PPDS
🇳🇿Auckland, New Zealand
Aotearoa Clinical Trials Trust
🇳🇿Auckland, New Zealand
Waikato Hospital
🇳🇿Hamilton, New Zealand
Centro de Investigacion Clinica Trujillo E.I.R.L.
🇵🇪Trujillo, La Libertad, Peru
Clinica San Juan Bautista
🇵🇪San Juan de Lurigancho, Lima, Peru
Hogar Clinica San Juan de Dios - Arequipa
🇵🇪Arequipa, Peru
Hospital Militar Central Luis Arias Schereiber
🇵🇪Lima, Peru
Clínica Internacional San Borja-Avenida Guardia Civil 385
🇵🇪Lima, Peru
Instituto Peruano del Hueso y la Articulacion S.A.C.
🇵🇪Lima, Peru
Instituto de Ginecologia y Reproduccion - PPDS
🇵🇪Lima, Peru
Alfredo Berrocal Kasay Reuma Sociedad de Responsabilidad Limitada
🇵🇪Pueblo Libre, Peru
Centrum Medyczne Oporow
🇵🇱Wroclaw, Dolnoslaskie, Poland
Dolnoslaski Szpital Specjalistyczny im. T. Marciniaka, Centrum Medycyny Ratunkowej
🇵🇱Wrocław, Dolnoslaskie, Poland
ETG Lublin - PPDS
🇵🇱Lublin, Lubelskie, Poland
Reumed Sp. z o.o. Poradnia Specjalistyczna Filia 2 Onyksowa
🇵🇱Lublin, Lubelskie, Poland
Malopolskie Centrum Kliniczne
🇵🇱Kraków, Malopolskie, Poland
FutureMeds - Warszawa Centrum - PPDS
🇵🇱Warszawa, Mazowieckie, Poland
MICS Centrum Medyczne Warszawa - MICS - PPDS
🇵🇱Warszawa, Mazowieckie, Poland
MTZ Clinical Research Powered by PRATIA - PPDS
🇵🇱Warszawa, Mazowieckie, Poland
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Dr hab. Med. Eleonory Reicher
🇵🇱Warszawa, Mazowieckie, Poland
Klinika Reuma Park sp . zoo Sp.k.
🇵🇱Warszawa, Mazowieckie, Poland
FutureMeds - Targowek - PPDS
🇵🇱Warszawa, Mazowieckie, Poland
K2J2 Medical Center
🇵🇱Wołomin, Mazowieckie, Poland
Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Sp. Z o.o.
🇵🇱Malbork, Pomorskie, Poland
Med-Polonia Sp. z o.o.
🇵🇱Poznan, Wielkopolskie, Poland
Prywatna Praktyka Lekarska Pawel Hrycaj
🇵🇱Poznan, Wielkopolskie, Poland
Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi Uniwersytetu Medycznego im. Karola M
🇵🇱Poznan, Wielkopolskie, Poland
Centrum Medyczne Poznan - PRATIA - PPDS
🇵🇱Skórzewo, Wielkopolskie, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Tadeusza Sokolowskiego Pomorskiego UM w Szczecinie
🇵🇱Szczecin, Zachodniopomorskie, Poland
MICS Centrum Medyczne Bydgoszcz
🇵🇱Bydgoszcz, Poland
Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Ambulatorium Sp z o.o.
🇵🇱Elblag, Poland
Centrum Medyczne Katowice - PRATIA - PPDS
🇵🇱Katowice, Poland
Centrum Medyczne Plejady Magdalena Celinska - Lowenhoff, Michal Zolnowski Spolka komandytowa
🇵🇱Kraków, Poland
Centrum Medyczne PROMED- Olszanska 5G
🇵🇱Kraków, Poland
Twoja Przychodnia PCM - ul. Marcelińska 92
🇵🇱Poznań, Poland
ETG Warszawa - PPDS
🇵🇱Warszawa, Poland
WIM-PIB, Centralny Szpital Kliniczny MON
🇵🇱Warszawa, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu - Borowska 213
🇵🇱Wroclaw, Poland
Pracownia Badan Klinicznych Salus
🇵🇱Wrocław, Poland
FutureMeds - Wroclaw - PPDS
🇵🇱Wrocław, Poland
FutureMeds - Lodz - PPDS
🇵🇱Łódź, Poland
ULS de Lisboa Ocidental, EPE - Hospital Egas Moniz
🇵🇹Lisbon, Lisboa, Portugal
Hospital Conde de Bertiandos - Unidade Local de saúde do Alto Minho, EPE - Ponte de Lima
🇵🇹Ponte de Lima, Viana Do Castelo, Portugal
Centro Hospitalar Universitário Lisboa Norte, E.P.E - PPDS
🇵🇹Lisboa, Portugal
ULS de Gaia/Espinho, EPE - Unidade I
🇵🇹Vila Nova de Gaia, Portugal
GCM Medical Group, PSC -62 Calle Jose Marti
🇵🇷San Juan, Puerto Rico
Institute of Rheumatology - PPDS
🇷🇸Belgrade, Serbia
Military Medical Academy
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia - Pasterova 2 - PPDS
🇷🇸Belgrade, Serbia
University Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Clinical Centre of Vojvodina
🇷🇸Novi Sad, Serbia
Special Hospital For Rheumatic Diseases Novi Sad
🇷🇸Novi Sad, Serbia
University Medical Centre Ljubljana
🇸🇮Ljubljana, Slovenia
University Clinical Centre Maribor
🇸🇮Maribor, Slovenia
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
C.H. Regional Reina Sofia - PPDS
🇪🇸Cordoba, Córdoba, Spain
Hospital Regional Universitario de Malaga - Hospital Civil
🇪🇸Malaga, Málaga, Spain
Hospital Universitario A Coruña
🇪🇸A Coruña, Spain
Hospital Universitario de Basurto
🇪🇸Bilbao, Spain
Hospital General Universitari de Castello
🇪🇸Castellón, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz - PPDS
🇪🇸Madrid, Spain
Fundacio Hospital de l'Esperit Sant
🇪🇸Santa Coloma De Gramenet(Barcelona), Spain
Hospital Universitario Hospiten Rambla de Tenerife
🇪🇸Santa Cruz de Tenerife., Spain
Hospital Universitario de Canarias
🇪🇸Santa Cruz de Tenerife, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Hospital Quironsalud Infanta Luisa
🇪🇸Sevilla, Spain
Hospital Nuestra Señora de Valme
🇪🇸Sevilla, Spain
Hospital Universitario Doctor Peset
🇪🇸Valencia, Spain
Luton and Dunstable University Hospital
🇬🇧Luton, Bedfordshire, United Kingdom
Hospital Universitario Araba - Txagorritxu
🇪🇸Vitoria, Álava, Spain
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Royal Free Hospital
🇬🇧London, Camden, United Kingdom
Chang Gung Memorial Hospital, Linkou
🇨🇳Gui Shan Qu, Taiwan
Kaohsiung Medical University - Chung-Ho Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
Taipei Medical University Hospital - PPDS
🇨🇳Taipei, Taiwan
Chapel Allerton Hospital
🇬🇧Leeds, United Kingdom
William Harvey Research Institute
🇬🇧London, United Kingdom
Royal Victoria Infirmary
🇬🇧Newcastle upon Tyne, United Kingdom
Queen's Medical Centre
🇬🇧Nottingham, United Kingdom
Queen Alexandra Hospital
🇬🇧Portsmouth, United Kingdom