Corticosteroid eye-drops for bacterial keratitis

Phase 4

Recruiting

• Conditions: Bacterial keratitis; Eye - Diseases / disorders of the eye; Infection - Other infectious diseases

• Registration Number: ACTRN12612000055808
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

Diagnosis of culture postivie bacterial keratitis, corneal defect less than or equal to 1.5mm and not within 1.0mm of the limbus, aged 16 or over, topical antibiotic given for at least three days with signs of clinical improvement.

Exclusion Criteria

Corneal perforation or impending perforation, descemetocele or endophthalmitis, evidence of herptic keratitis, fungal, or acanthambeoba infection by exam or history, pre-existing corneal scar, use of topical steriod in affected eye or systemic corticosteriod during course of present infection, aged under 16 years, bilateral corneal infections, previous penetrating corneal transplant, pregnancy, best corrected vision worse than 6/60 in fellow eye, allergy to study drugs, uncontrolled systemic disease, concurrent ocular infections and patients requiring treatment with subconjuctival injection.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to corneal healing (re-epithelisation).<br><br>This outcome will be assessed by slit lamp examination of the cornea with topical fluoroscein dye, and anterior chamber optical coherence tomography (OCT), which will allow exact measurements of the corneal lesion to be recorded[Baseline, and at 4, 7, 14, 21 and 90 days following study enrolment]