Inhibitory Functions as Predictors of Chronic Pain: a Pilot Study

Recruiting

Conditions: Postoperative
chronic pain
10017998

Registration Number: NL-OMON38768

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Scheduled for pancreatic resection surgery for (pre)cancer

Exclusion Criteria

• Inability to speak/understand the Dutch language.
• Severe psychiatric problems
• Neurodegenerative disorders
• Substance abuse
• History of stroke
• Previous major abdominal or thoracic surgery
• Current chronic pain condition

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study outcome parameter is the presence and severity of pain, assessed<br /><br>with visual analogue scales, 7 to 10 days after and three months after surgery.<br /><br>Preoperative endogenous inhibitory functions will form the predictors of acute<br /><br>and persistent postoperative pain and will consist of three different<br /><br>measurements: 1. cognitive inhibition as measured with the Stroop taks and with<br /><br>the Go/No-Go task, to measure interference control and prepotent response<br /><br>inhibition respectively; 2. Conditioned Pain Modulation (CPM) in order to<br /><br>examine the extent to which a painful stimulation (cold pressor test) inhibits<br /><br>to experience of another painful stimulation (second PPT and EPTT, compared to<br /><br>the first PPT and EPTT), and; 3. Placebo- and nocebo-suggestions, to examine<br /><br>the extent to which expectations inhibit (placebo) or facilitate (nocebo, by<br /><br>diminishing inhibitory functions) pain experience.</p><br>

Secondary Outcome Measures