A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer

Phase 3

Completed

Conditions: Gastric Cancer
Gastroesophageal Junction Cancer

Interventions: Drug: BBI608
Drug: Paclitaxel
Other: Placebo

Registration Number: NCT02178956

Lead Sponsor: Sumitomo Pharma America, Inc.

Brief Summary: The purpose of this study is to find out whether it is better to receive a new drug, BBI608, in addition to paclitaxel chemotherapy or better to receive paclitaxel chemotherapy alone as second line treatment for gastric and gastroesophageal junction cancer after prior first line platinum and fluoropyrimidine based chemotherapy.

Detailed Description: The goal of this study is to determine if paclitaxel given together with BBI608 as second line therapy will prolong overall survival compared to paclitaxel alone.

Approximately 700 patients will be randomized with histologically or cytologically confirmed metastatic gastric or gastroesophageal junction adenocarcinoma.

Patients must have failed first line therapy with any platinum/fluoropyrimidine doublet.

BBI608/placebo will be administered daily, paclitaxel will be administered i.v. on days 1, 8 and 15 of a 4 weekly cycle.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 714

Inclusion Criteria

Cytologically or histologically confirmed advanced gastric or GEJ adenocarcinoma that is metastatic or locally advanced and unresectable.
Failed treatment with one regimen containing at least a platinum/fluoropyrimidine doublet for unresectable or metastatic disease.Treatment failure is defined as progression of disease (clinical or radiologic) during first line treatment for unresectable or metastatic disease or ≤ 6 months after last dose of first line treatment.
Paclitaxel therapy is appropriate for the patient and is recommended by the Investigator.
Imaging investigations including CT/MRI of chest/abdomen/pelvis or other scans as necessary to document all sites of disease done within 21 days prior to randomization. Patients with either measurable disease OR non-measurable evaluable disease will be eligible.
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

･≥ 18 years of age.
For male or female patient of child producing potential: Must agree to use contraception or take measures to avoid pregnancy during the study and for 6 months after the final dose of Paclitaxel or for 30 days for female patients and for 90 days for male patients, of the final BBI608/Placebo dose if Paclitaxel was not administered.
Women of child bearing potential (WOCBP) must have a negative serum or urine pregnancy test within 5 days prior to randomization.
Alanine transaminase (ALT) ≤ 3 × institutional upper limit of normal (ULN) [≤ 5 × ULN in presence of liver metastases] within 14 days prior to randomization.
Hemoglobin (Hgb) ≥ 9.0 g/dL within 14 days prior to randomization. Must not have required transfusion within 1 week of baseline Hgb assessment.
Total bilirubin ≤ 1.5 × institutional ULN [≤ 2.0 x ULN in presence of liver metastases] within 14 days prior to randomization.
Creatinine ≤ 1.5 × institutional ULN or Creatinine Clearance > 50 ml/min (as calculated by the Cockroft-Gault equation) within 14 days prior to randomization.
Absolute neutrophil count ≥ 1.5 x 10^9/L within 14 days prior to randomization.
Platelet count ≥ 100 x 10^9/L within 14 days prior to randomization. Must not have required transfusion within 1 week of baseline platelet assessment.
Other baseline laboratory evaluations must be done within 14 days prior to randomization.
Patient must consent to provision of a representative formalin fixed paraffin block of tumor tissue, if available, in order that the specific correlative marker assays may be conducted.
Patient must consent to provision of a sample of blood in order that the specific correlative marker assays may be conducted.
Patients must be accessible for treatment and follow up.
Protocol treatment is to begin within 2 working days of patient randomization.
The patient is not receiving therapy in a concurrent clinical study and the patient agrees not to participate in other interventional clinical studies during their participation in this trial while on study treatment. Patients participating in surveys or observational studies are eligible to participate in this study.

Exclusion Criteria

Anti-cancer chemotherapy or biologic therapy if administered prior to the first planned dose of BBI608/placebo within period of time equivalent to the usual cycle length of the regimen. An exception is made for oral fluoropyrimidines (e.g. capecitabine, S-1), where a minimum of 10 days since last dose must be observed prior to the first planned dose of BBI608/placebo.Radiotherapy, immunotherapy, or investigational agents within four weeks of first planned dose of BBI608/placebo, with the exception of a single dose of radiation up to 8 Gray (equal to 800 RAD) with palliative intent for pain control up to 14 days before randomization.
Prior taxanes in the neoadjuvant or adjuvant setting with progression occurring within 6 months of completion of taxane therapy; or any taxanes in the metastatic setting.
More than one prior chemotherapy regimen administered in the metastatic setting.
Major surgery within 4 weeks prior to randomization.
Any known symptomatic brain metastases requiring steroids.
Women who are pregnant or breastfeeding.
Gastrointestinal disorder(s) which, in the opinion of the Qualified/Principal Investigator, would significantly impede the absorption of an oral agent.
Unable or unwilling to swallow BBI608/placebo capsules daily.
Uncontrolled intercurrent illness.
Peripheral neuropathy ≥ CTCAE Grade 2 at baseline.
History of other malignancies except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for ≥ 3 years.
Prior treatment with BBI608.
Any active disease condition which would render the protocol treatment dangerous or impair the ability of the patient to receive protocol therapy.
Any condition (e.g. psychological, geographical, etc.) that does not permit compliance with the protocol.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
BBI608 plus Paclitaxel	Paclitaxel	-
Placebo plus Paclitaxel	Paclitaxel	-
Placebo plus Paclitaxel	Placebo	-
BBI608 plus Paclitaxel	BBI608	-

Primary Outcome Measures

Name	Time	Method
Overall Survival	36 months	The primary objective of this study is to assess the effect of orally administered BBI608 plus weekly paclitaxel, in comparison to placebo plus weekly paclitaxel on the Overall Survival of patients with advanced histopathologically confirmed gastric or gastroesophageal junction adenocarcinoma who failed treatment with one platinum/fluoropyrimidine containing regimen for unresectable or metastatic disease.

Secondary Outcome Measures

Name	Time	Method
Objective Response Rate	36 months	Objective Response Rate is defined as the percentage of patients with a documented complete response or partial response (CR + PR) based on RECIST 1.1.
Disease Control Rate	36 months	Disease control Rate is defined as the percentage of patients with a documented complete response or partial response (CR + PR+SD) based on RECIST 1.1.
Progression Free Survival	36 months	Defined as the time from randomization to the first objective documentation of disease progression or death due to any cause which comes first. Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria(RECIST v1.1), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in anon-target lesion, or the appearance of new lesions.
Number of Patients With Adverse Events	36 months	All patients who have received at least one dose of BBI608/Placebo will be included in the safety analysis. The number of patients who experienced at least one adverse event is reported.

Trial Locations

Locations (261): Metro-Minnesota NCI CORP
🇺🇸
Saint Louis Park, Minnesota, United States
Multiprofile hospital for active treatment
🇧🇬
Sofia, Bulgaria
Institutul Regional de Oncologie Iasi
🇷🇴
Lasi, Romania
SPb State Budget Institution Oncology Dispansery
🇷🇺
Saint Petersburg, Sankt-Petersburg, Russian Federation
West China Hospital, Sichuan University
🇨🇳
Chengdu, Sichuan, China
Masarykuv onkologicky ustav
🇨🇿
Brno, Czechia
Swedish Cancer Institute/ Swedish Health Services
🇺🇸
Seattle, Washington, United States
Ohio State University Medical Center
🇺🇸
Columbus, Ohio, United States
Tianjin Medical University Cancer Institute & Hospital
🇨🇳
Tianjin, Tianjin, China
Hospital da Cidade de Passo Fundo
🇧🇷
Passo Fundo, Rio Grande Do Sul, Brazil
Fiona Stanley Hospital
🇦🇺
Subiaco, Western Australia, Australia
IRCCS Ospedale Oncologico "Giovanni Paolo II"
🇮🇹
Bari, Italy
Humanitas Gavazzeni
🇮🇹
Bergamo, Italy
Ospedale Guglielmo da Saliceto, AUSL Piacenza
🇮🇹
Piacenza, Italy
Unità di Biostatistica e Sperimentazioni Cliniche IRST
🇮🇹
Ravenna, Italy
Mayo Clinic - Arizona
🇺🇸
Scottsdale, Arizona, United States
Northern Indiana Cancer Research Consortium
🇺🇸
South Bend, Indiana, United States
Heartland NCORP
🇺🇸
Saint Louis, Missouri, United States
Weill Medical College of Cornell University
🇺🇸
New York, New York, United States
St. Mary's Hospital
🇺🇸
Green Bay, Wisconsin, United States
Siouxland Regional Cancer Center
🇺🇸
Sioux City, Iowa, United States
Cancer Center of Kansas
🇺🇸
Wichita, Kansas, United States
Ochsner NCI CORP
🇺🇸
New Orleans, Louisiana, United States
Munson Medical Center
🇺🇸
Traverse City, Michigan, United States
Saint Vincent Hospital CCOP
🇺🇸
Green Bay, Wisconsin, United States
New Hampshire Oncology Hematology - Laconia
🇺🇸
Laconia, New Hampshire, United States
State University of New York Upstate Medical University
🇺🇸
Syracuse, New York, United States
Bankstown-Lidcombe
🇦🇺
Bankstown, New South Wales, Australia
Marshfield CCOP
🇺🇸
Marshfield, Wisconsin, United States
Royal North Shore Hospital
🇦🇺
St Leonards, New South Wales, Australia
Riverina Cancer Care Centre
🇦🇺
Wagga Wagga, New South Wales, Australia
Sunshine Coast Hospital and Health Service
🇦🇺
Nambour, Queensland, Australia
Chris O'Brien Lifehouse
🇦🇺
Camperdown, New South Wales, Australia
St Vincent's Hospital
🇦🇺
Fitzroy, Victoria, Australia
Gold Coast University Hospital
🇦🇺
Southport, Queensland, Australia
Royal Brisbane & Women's Hospital
🇦🇺
Herston, Queensland, Australia
Port Macquaries Base Hospital
🇦🇺
Port Macquarie, New South Wales, Australia
Townsville Hospital
🇦🇺
Townsville, Queensland, Australia
Sunshine Hospital
🇦🇺
St Albans, Victoria, Australia
Royal Melbourne Hospital
🇦🇺
Parkville, Victoria, Australia
Clinica de Neoplasias Litoral
🇧🇷
Itajai, Santa Catarina, Brazil
Cetus Hospital Dia Oncologia
🇧🇷
Belo Horizonte, Minas Gerais, Brazil
Casa de Saúde Santa Marcelina
🇧🇷
São Paulo, Brazil
CHU Ambroise Paré
🇧🇪
Mons, Hainaut, Belgium
Oncovida - Centro de Oncologia da Bahia
🇧🇷
Salvador, Bahia, Brazil
Hospital Bruno Born
🇧🇷
Lajeado, Rio Grande Do Sul, Brazil
UPCO - Unidade de Pesquisa Clinica em Oncologia LTDA
🇧🇷
Pelotas, Rio Grande Do Sul, Brazil
UMHAT ""Dr. Georgi Stranski"" Dept. Medical Oncology
🇧🇬
Pleven, Bulgaria
UMHAT"Sv.Ivan Rilski"
🇧🇬
Sofia, Bulgaria
Inca-RJ
🇧🇷
Rio de Janeiro, Brazil
Specialised Hospital for Active Treatment in Oncology
🇧🇬
Sofia, Sofia-Grad, Bulgaria
District Dispensery with Stationary - Sofia District
🇧🇬
Sofia, Bulgaria
Jiangsu Province Hospital
🇨🇳
Nanjing, Jiangsu, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳
Zhengzhou, Henan, China
Henan Cancer Hospital
🇨🇳
Zhengzhou, Henan, China
COC - Vratsa Dept. of Palliative Care
🇧🇬
Vratsa, Bulgaria
McGill University Health Centre - Montreal General Hospital
🇨🇦
Montreal, Quebec, Canada
Hopital Notre-Dame du CHUM
🇨🇦
Montreal, Quebec, Canada
The 307th Hospital of Chinese People's Liberation Army
🇨🇳
Beijing, Beijing, China
Hunan Cancer Hospital
🇨🇳
Changsha, Hunan, China
Sir Run Run Shaw Hospital School of Medicine, Zhejiang University
🇨🇳
Hangzhou, Zhejiang, China
The 81 Hospital of the Chinese People's Liberation Army
🇨🇳
Nanjing, Jiangsu, China
Jiang Su Cancer Hospital
🇨🇳
Nanjing, Jiangsu, China
Xin Jiang Tumor Hospital, Xin Jiang Medical University
🇨🇳
Urumqi, Xinjiang, China
Tongji Hospital
🇨🇳
Wuhan, China
Zhejiang Cancer Hospital
🇨🇳
Hangzhou, Zhejiang, China
Nemocnice Na Bulovce
🇨🇿
Praha 8, Czechia
Centre Antoine Lacassagne
🇫🇷
Nice, Alpes-Maritimes, France
Hopital Saint Joseph - Marseille
🇫🇷
Marseille, Bouches-du-Rhône, France
Hopital Privé Jean Mermoz
🇫🇷
Lyon, Rhône, France
Klinikum Bogenhausen
🇩🇪
München, Bayern, Germany
Hôpital Morvan - CHRU de Brest
🇫🇷
Brest Cedex, France
Hospital of Poitiers
🇫🇷
Poitiers, Vienne, France
CHU Saint Etienne
🇫🇷
Saint Etienne, France
Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital
🇫🇷
Toulouse cedex, France
Institut Gustave Roussy
🇫🇷
Villejuif, France
Ev. Krankenhaus Bielefeld
🇩🇪
Bielefeld, Nordrhein-Westfalen, Germany
Klinikum der Johann Wolfgang Goethe-Universität
🇩🇪
Frankfurt/Main, Hessen, Germany
Charite
🇩🇪
Berlin, Germany
Békés Megyei Pándy Kálmán Kórház
🇭🇺
Gyula, Békés, Hungary
Kliniken Essen-Mitte Evang. Huyssens-Stiftung
🇩🇪
Essen, Nordrhein-Westfalen, Germany
Johannes Gutenberg-Universitaet
🇩🇪
Maintz, Rheinland-Pfalz, Germany
Universitätsklinikum Leipzig
🇩🇪
Leipzig, Sachsen, Germany
Charite - Campus Benjamin Franklin (Cbf)
🇩🇪
Berlin, Germany
Pécsi Tudományegyetem Klinikai Központ
🇭🇺
Pécs, Baranya, Hungary
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház- Rendelőinté
🇭🇺
Szolnok, Jász-Nagykun-Szolnok, Hungary
Josa Andras Oktato Korhaza
🇭🇺
Nyiregyhaza, Szabolcs-Szatmár-Bereg, Hungary
Irccs Irst
🇮🇹
Meldola, Forli, Italy
Soroka Medical Center [Oncology]
🇮🇱
Beer Sheva, HaDarom, Israel
The E. Wolfson Medical Center [Oncology]
🇮🇱
Holon, HaMerkaz, Israel
Egyesített Szent István és Szent László Kórház-Rendelőintéze
🇭🇺
Budapest, Hungary
Ospedale Umberto I, AOU Ospedali Riuniti Umberto I - GM.Lanc
🇮🇹
Ancona, Italy
Meir Medical Center
🇮🇱
Kfar Saba, HaMerkaz, Israel
Rabin Medical Center - Beilinson Hospital
🇮🇱
Petah Tikva, HaMerkaz, Israel
Tel Aviv Sourasky Medical Center
🇮🇱
Tel Aviv, Tel-Aviv, Israel
Hadassah Medical Organisation
🇮🇱
Jerusalem, Yerushalayim, Israel
PO Garibaldi-Nesima, ARNAS Garibaldi
🇮🇹
Catania, Italy
CHU Estaing
🇫🇷
Clermont-Ferrand, France
AUSL della Romagna, Osp. degli Infermi
🇮🇹
Faenza, Ravenna, Italy
National Hospital Organization Shikoku Cancer Center
🇯🇵
Matsuyama, Ehime, Japan
Azienda Ospedaliera "Istituti Ospitalieri" di Cremona
🇮🇹
Cremona, Italy
AOU S.Martino, IRCCS, IST-Istituto Nazionale Ricerca Sul Can
🇮🇹
Genova, Italy
Ospedale Molinette, AO Città della Salute e della Scienza di
🇮🇹
Torino, Italy
Azienda Ospedaliera Fatebenefratelli e Oftalmico
🇮🇹
Milano, Italy
Istituto Oncologico Veneto IOV-IRCCS
🇮🇹
Padova, Italy
Osaka University Hospital
🇯🇵
Suita, Osaka, Japan
Aichi Cancer Center Hospital
🇯🇵
Nagoya, Aichi, Japan
Kobe City Medical Center General Hospital
🇯🇵
Kobe, Hyogo, Japan
Shizuoka Cancer Center
🇯🇵
Sunto, Shizuoka, Japan
Klaipeda University Hospital
🇱🇹
Klaipeda, Lithuania
Seoul National University Bundang Hospital
🇰🇷
SeongNam, Gyeonggido, Korea, Republic of
Kyorin University Hospial
🇯🇵
Mitaka, Tokyo, Japan
Chiba Cancer Center
🇯🇵
Chiba, Japan
Osaka Medical Center for Cancer and Cardiovascular Diseases
🇯🇵
Osaka, Japan
Samsung Medical Center
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
National Cancer Institute
🇱🇹
Vilnius, Vilniaus Apskritis, Lithuania
Asan medical Center
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
Gifu University Hospital
🇯🇵
Gifu, Japan
Hospital of Lithuanian University of Health sciences
🇱🇹
Kaunas, Kauno Apskritis, Lithuania
Spitalul Clinic CF 2
🇷🇴
Bucuresti, Romania
Siauliai County Hospital
🇱🇹
Siauliai, Šiauliu Apskritis, Lithuania
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie
🇵🇱
Warszawa, Mazowieckie, Poland
Zachodniopomorskie Centrum Onkologii
🇵🇱
Szczecin, Zachodniopomorskie, Poland
Oncomed
🇷🇴
Timisoara, Timis, Romania
Spitalul Clinic Municipal de Urgenta Timisoara
🇷🇴
Timisoara, Timis, Romania
Spitalul Clinic Judetean de Urgenta Sibiu
🇷🇴
Sibiu, Romania
GUZ Perm Regional Oncology Dispensary
🇷🇺
Perm, Permskiy Kray, Russian Federation
City Clinical Hospital #40
🇷🇺
Moscow, Moskva, Russian Federation
First Pavlov State Medical University of Saint-Petersburg
🇷🇺
Saint Petersburg, Sankt-Peterburg, Russian Federation
H.U.V. Macarena
🇪🇸
Sevilla, Andalucía, Spain
C.A.AV-H.Ntra.Sra.de Sonsoles
🇪🇸
Avila, Castilla Y León, Spain
H.Sta.Creu i St.Pau
🇪🇸
Barcelona, Spain
H.del Mar
🇪🇸
Barcelona, Spain
Hospital Universitario Vall d'Hebrón
🇪🇸
Barcelona, Spain
Royal Surrey County Hospital
🇬🇧
Guildford, Surrey, United Kingdom
Southampton University Hospital
🇬🇧
Southampton, United Kingdom
Institut Catalá d´Oncología (I.C.O.)
🇪🇸
Hospitalet de Llobregat, Spain
H.U.V.Arrixaca
🇪🇸
Murcia, Spain
H.U. de Burgos
🇪🇸
Burgos, Spain
C.H.G.U.de Valencia
🇪🇸
Valencia, Spain
H.G.U. G. Marañón
🇪🇸
Madrid, Spain
H.U.V. del Rocío
🇪🇸
Sevilla, Spain
H.C. S.Carlos
🇪🇸
Madrid, Spain
H.U. R. y Cajal
🇪🇸
Madrid, Spain
M.D. Anderson Cancer Center Madrid
🇪🇸
Madrid, Spain
Aberdeen Royal Infirmary
🇬🇧
Aberdeen, Aberdeen City, United Kingdom
H.U. Miguel Servet
🇪🇸
Zaragoza, Spain
The Beatson West Of Scotland Cancer Centre
🇬🇧
Glasgow, Glasgow City, United Kingdom
The Royal Marsden Hospital
🇬🇧
Sutton, Surrey, United Kingdom
Belfast City Hospital
🇬🇧
Belfast, United Kingdom
St. Georges Hospital
🇬🇧
London, United Kingdom
The Ottawa Hospital Cancer Centre
🇨🇦
Ottawa, Ontario, Canada
Saint Michael's Hospital Li Ka Shing Knowledge Institute
🇨🇦
Toronto, Ontario, Canada
Mount Sinai Hospital
🇨🇦
Toronto, Ontario, Canada
Princess Margaret Hospital
🇨🇦
Toronto, Ontario, Canada
IEP São Lucas
🇧🇷
São Paulo, Brazil
Seoul National University Hospital
🇰🇷
Seoul, Seoul Teugbyeolsi, Korea, Republic of
Universitätsklinik Carl-Gustav-Carus Dresden
🇩🇪
Dresden, Sachsen, Germany
The University of Oklahoma Health Sciences Center (OUHSC)
🇺🇸
Oklahoma City, Oklahoma, United States
Colorado Cancer Research Program
🇺🇸
Denver, Colorado, United States
Mayo Clinic - Rochester
🇺🇸
Rochester, Minnesota, United States
Indiana University Health Goshen Center For Cancer Care
🇺🇸
Goshen, Indiana, United States
Indiana University Health University Hospital
🇺🇸
Chapel Hill, North Carolina, United States
New Hampshire Oncology Hematology - Concord
🇺🇸
Concord, New Hampshire, United States
Geisinger Medical Center
🇺🇸
Danville, Pennsylvania, United States
Virginia Mason Medical Center
🇺🇸
Seattle, Washington, United States
Gundersen Lutheran Medical Center
🇺🇸
La Crosse, Wisconsin, United States
Central coast area health (public)
🇦🇺
Gosford, New South Wales, Australia
Flinders Medical Centre
🇦🇺
Bedford Park, South Australia, Australia
Princess Alexandra Hospital
🇦🇺
Woolloongabba, Queensland, Australia
The Queen Elizabeth Hospital
🇦🇺
Woodville, South Australia, Australia
Austin Hospital
🇦🇺
Heidelberg, Victoria, Australia
Peninsula & South Eastern Haematology and Oncology Group
🇦🇺
East Bentleigh, Victoria, Australia
Bendigo Hospital
🇦🇺
Bendigo, Victoria, Australia
Ballarat base hospital
🇦🇺
Heidelberg, Victoria, Australia
Ashford Cancer Centre Research
🇦🇺
Kurralta Park, South Australia, Australia
Monash Health
🇦🇺
East Bentleigh, Victoria, Australia
Ballarat Oncology and Haematology Services
🇦🇺
Wendouree, Victoria, Australia
Imelda Ziekenhuis
🇧🇪
Bonheiden, Antwerpen, Belgium
UZ Brussel - Campus Jette
🇧🇪
Brussel, Brussels Capital Region, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪
Bruxelles, Brussels Capital Region, Belgium
AZ Sint-Lucas - Campus Sint-Lucas
🇧🇪
Brugge (Assebroek), Belgium
Institut Jules Bordet
🇧🇪
Bruxelles, Brussels Capital Region, Belgium
CHU de Liège - Domaine Universitaire du Sart Tilman
🇧🇪
Liège, Belgium
Instituto do Câncer do Ceará - Instituto do Câncer do Cear
🇧🇷
Fortaleza, Ceará, Brazil
Fundaçao dr Amaral Carvalho
🇧🇷
Jaú, São Paulo, Brazil
Hospital de Base de São José do Rio Preto
🇧🇷
São José do Rio Preto, São Paulo, Brazil
Harbin Medical University Cancer Hospital
🇨🇳
Heilongjiang, Heilongjiang, China
Cancer Hospital Chinese Academy of Medical Sciences
🇨🇳
Beijing, Beijing, China
Beijing Cancer Hospital
🇨🇳
Beijing, Beijing, China
Southern Medical University, Nanfang Hospital
🇨🇳
Guangzhou, Guangdong, China
Sun Yat-Sen University Cancer Center
🇨🇳
Guangzhou, Guangdong, China
Fujian Medical University Union Hospital
🇨🇳
Fuzhou, Fujian, China
Chinese PLA General Hospital
🇨🇳
Beijing, Beijing, China
The First Bethune Hospital of Jilin University
🇨🇳
Changchun, Jilin, China
Jilin Cancer Hospital
🇨🇳
Jilin, Jilin, China
The First Hospital of China Medical University
🇨🇳
Shenyang, Liaoning, China
Fudan University Shanghai Cancer Center
🇨🇳
Shanghai, Shanghai, China
Zhongshan Hospital
🇨🇳
Shanghai, Shanghai, China
General Hospital of Ningxia Medical University
🇨🇳
Yinchuan, Ningxia, China
FN Hradec Kralove
🇨🇿
Hradec Kralove, Královéhradecký Kraj, Czechia
Fakultni nemocnice Olomouc
🇨🇿
Olomouc, Olomoucký Kraj, Czechia
East Tallinn Central Hospital Oncology Center
🇪🇪
Tallinn, Harjumaa, Estonia
Tartu University Hospital Clinic of Hematology and Oncology
🇪🇪
Tartu, Tartumaa, Estonia
Vseobecna fakultni nemocnice v Praze
🇨🇿
Praha 2, Czechia
Centre Paul Papin
🇫🇷
St Herblain Cedex, Loire-Atlantique, France
Centre Rene Gauducheau
🇫🇷
St Herblain Cedex, Loire-Atlantique, France
Centre Hospitalier De Mont De Marsan - Hopital Layné
🇫🇷
Mont de Marsan Cedex, France
CHU - Hôpital De La Timone
🇫🇷
Marseille, France
Centre eugène marquis
🇫🇷
Rennes, France
OncoResearch Lerchenfeld GmbH
🇩🇪
Hamburg, Germany
Petz Aladár Megyei Oktató Kórház
🇭🇺
Gyor, Gyor-Moson-Sopron, Hungary
Debreceni Egyetem Klinikai Központ
🇭🇺
Debrecen, Hajdú-Bihar, Hungary
Facharztzentrum Eppendorf
🇩🇪
Hamburg, Germany
Klinikum Esslingen
🇩🇪
Esslingen, Germany
Semmelweis Egyetem
🇭🇺
Budapest, Hungary
Országos Onkológiai Intézet
🇭🇺
Budapest, Hungary
Somogy Megyei Kaposi Mór Oktató Kórház
🇭🇺
Kaposvár, Hungary
Policlinico S.Orsola Malpighi, AOU di Bologna
🇮🇹
Bologna, Italy
Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onko
🇵🇱
Brzozow, Podkarpackie, Poland
Centrul de Oncologie Sf. Nectarie
🇷🇴
Craiova, Dolj, Romania
Tochigi Cancer Center
🇯🇵
Utsunomiya, Tochigi, Japan
Saku Central Hospital Advanced Care Center
🇯🇵
Saku, Nagano, Japan
Saitama Cancer Center
🇯🇵
Kita-Adachi, Saitama, Japan
National Cancer Center Hospital
🇯🇵
Chuo, Tokyo, Japan
Hokkaido University Hospital
🇯🇵
Sapporo, Hokkaido, Japan
Republican Clinical Oncology Dispensary
🇷🇺
Ufa, Bahkortostan, Respublika, Russian Federation
Northwestern State Medical University n.a. Mechnikov
🇷🇺
Saint Petersburg, Sankt-Peterburg, Russian Federation
H.U.P Hierro-Majadahonda
🇪🇸
Majadahonda, Madrid, Spain
Military Medical Academy n.a. S.M. Kirov
🇷🇺
Saint Petersburg, Leningradskaya Oblast', Russian Federation
GBUZ Saint Petersburg clinical scientific and practical cent
🇷🇺
Saint Petersburg, Sankt-Peterburg, Russian Federation
Guz Clinical Oncology Dispensary #1
🇷🇺
Krasnodar, Russian Federation
Christie Hospital NHS Foundation Trust
🇬🇧
Manchester, United Kingdom
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital
🇬🇧
Sutton, Surrey, United Kingdom
UZ Antwerpen
🇧🇪
Edegem, Antwerpen, Belgium
Hospital Erasto Gaertner
🇧🇷
Curitiba, Paraná, Brazil
UZ Leuven - Campus Gasthuisberg
🇧🇪
Leuven, Vlaams Brabant, Belgium
Chd Vendee La Roche Sur Yon
🇫🇷
La Roche sur Yon Cedex 9, Vendée, France
Rambam Health Care Campus
🇮🇱
Haifa, Israel
National Cancer Center Hospital East
🇯🇵
Kashiwa, Chiba, Japan
Hospital of Lithuanian University of Health Sciences
🇱🇹
Kaunas, Kauno Apskritis, Lithuania
Respublikine Panevezio ligonine
🇱🇹
Panevezys, Panevežio Apskritis, Lithuania
Uni. Multiprofile Hospital for Active treatment Sveta Marina
🇧🇬
Varna, Bulgaria
Vilniaus Universiteto ligonines Santariskiu Klinikos
🇱🇹
Vilnius, Lithuania
Centrum Onkologii im. F.Lukaszczyka
🇵🇱
Bydgoszcz, Kujawsko-pomorskie, Poland
Szpital Specjalistyczny im. L. Rydygiera w Krakowie
🇵🇱
Krakow, Malopolskie, Poland
Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina
🇵🇱
Otwock, Mazowieckie, Poland
Wojewodzki Szpital Specjalistyczny im. M.Kopernika
🇵🇱
Lodz, Łódzkie, Poland
Sp. Jud. de Urg. "Dr. Constantin Opris" Baia Mare
🇷🇴
Baia-Mare, Maramures, Romania
Med Life
🇷🇴
Bucuresti, Romania
Centrul de Oncologie Euroclinic
🇷🇴
Iasi, Romania
Institut Català d'Oncologia-Hospital Germans Trias i Pujol
🇪🇸
Badalona, Barcelona, Spain
Magodent sp. z o.o. Szpital Onkologiczny
🇵🇱
Warszawa, Mazowieckie, Poland
Wojewodzkie Centrum Onkologii w Gdansku
🇵🇱
Gdansk, Pomorskie, Poland
Institutul Clinic Fundeni
🇷🇴
Bucuresti, Romania
Russian Oncological Research Center n.a. N.N. Blokhin RAMS
🇷🇺
Moscow, Moskva, Russian Federation
NZOZ Centrum Medyczne HCP Lecznictwo Stacjonarne
🇵🇱
Poznan, Wielkopolskie, Poland
Radiotherapy Center CJ radioterapie si chimioterapie adulti
🇷🇴
Floresti, Cluj, Romania
Oncolab
🇷🇴
Craiova, Dolj, Romania
GBUZ of Stavropol Territory Pyatigorsk Oncology Dispensary
🇷🇺
Pyatigorsk, Stavropol'skiy Kray, Russian Federation
Spectrum Health Butterworth
🇺🇸
Grand Rapids, Michigan, United States