Comparisons the Analgesia of Paravertebral Block Combined With Thoracic Wall Block Versus Paravertebral Block Alone for Modified Radical Mastectomy in Breast Cancer

Sun Yat-sen University0 sites100 target enrollmentOctober 2015

ConditionsMastectomy, Modified Radical

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Mastectomy, Modified Radical
Sponsor: Sun Yat-sen University
Enrollment: 100
Primary Endpoint: intraoperative sedation requirement
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

Previous studies have shown that PVB reduces pain and postoperative nausea and vomiting after breast cancer surgery when used in addition to general anesthesia or sedation. However, major breast cancer surgery involves areas beyond the breast tissue, such as pectoral musculature.

Registry

clinicaltrials.gov

Start Date

October 2015

End Date

February 2016

Last Updated

10 years ago

Study Type

Observational

Sex

Female

Investigators

Sponsor

Sun Yat-sen University

Responsible Party

Principal Investigator

Nai Liang Li

Sun Yat-sen University

Eligibility Criteria

Inclusion Criteria

•The American Society of Anesthesiologists (ASA) Physical Status classification I to III
•20 - 75 years of age
•female gender

Exclusion Criteria

•body mass index (BMI) ≥ 35 kg/m2
•modified radical mastectomy not performed by the single surgeon (Ben Long Yu)
•anesthesia not performed by the single anesthesiologist (Nai Liang Li)

Outcomes

Primary Outcomes

intraoperative sedation requirement

Time Frame: during operation

target controlled infusion (TCI) propofol driven by the Schnider model in effect site control titrated to reach conscious sedation defined as Observer Assessment of Alertness/Sedation score of 2 to 3